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Acta diabetologia latina

, Volume 26, Issue 1, pp 79–81 | Cite as

The first experimental diabetes mellitus

  • Fritz S. Keck
  • Ernst F. Pfeiffer
Historical Note

Summary

In the history of diabetes research, surgically induced experimental diabetes is usually associated with the names of Minkowski and von Mering on the basis of their investigations in 1889. However, temporary diabetes mellitus had already been induced 200 years previously by Johann Conrad Brunner (1653–1727) in an experiment in dogs. According to present-day knowledge, this temporary diabetes mellitus must be ascribed to subtotal pancreatectomy and reversible traumatic damage to the remaining endocrine pancreas. The brilliant experimenter Brunner did not associate the symptoms he produced with diabetes. Diabetes research would possibly have taken a different course had he done so.

Key-words

Diabetes mellitus Dog experiments Historical review Pancreas ligature Pancreatectomy Temporary diabetic condition 

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References

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Copyright information

© Casa Editrice Il Ponte 1989

Authors and Affiliations

  • Fritz S. Keck
    • 1
  • Ernst F. Pfeiffer
    • 1
  1. 1.Abteilung Innere Medizin IMedizinische Klinik und Poliklinik der UniversitätUlmFRG

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