Acta diabetologia latina

, Volume 20, Issue 4, pp 311–320 | Cite as

Preclinical abnormality of left ventricular performance in patients with insulin-dependent diabetes mellitus

  • György Jermendy
  • László Kammerer
  • Szófia M. Koltai
  • Livia Cserhalmi
  • Judit Szelényi
  • Maria Tichy
  • Gábor Pogátsa
Original Contributions
Received:

Summary

The left ventricular systolic function of 32 patients with insulin-dependent diabetes mellitus was investigated by measurement of systolic time intervals. Patients with clinical signs of sclerosis in the coronary arteries were excluded. Twenty-nine sex- and age-matched healthy people served as controls. Resting values of PEP/LVET ratio and of the corrected pre-ejection period were significantly higher in diabetics than in controls. The alterations of systolic time intervals during volume-loading induced by passive leg-raising as well as by isometric handgrip test indicated an increase in left ventricular performance in healthy people. The unchanged systolic time intervals observed in diabetics during the same loadings indicated a decrease in the functional reserve of the diabetic left ventricle. The systolic time intervals observed in patients with type-1 diabetes could be evaluated as a preclinical abnormality of left ventricular performance and as early signs of diabetic cardiomyopathy.

Key-words

Diabetic cardiomyopathy Handgrip test Insulin-dependent diabetes mellitus Systolic time intervals Volume-loading 
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Copyright information

© Casa Editrice Il Ponte 1983

Authors and Affiliations

  • György Jermendy
    • 1
  • László Kammerer
    • 1
  • Szófia M. Koltai
    • 1
  • Livia Cserhalmi
    • 1
  • Judit Szelényi
    • 1
  • Maria Tichy
    • 1
  • Gábor Pogátsa
    • 1
  1. 1.Fővárosi István Kórház-Rendelóintézet, II. Belgyógyászati Osztály, Országos Kardiológiai Intézet, Diagnosztikai és Kutatási OsztályOrszágos Haematológiai és Vértranszfuziós Intézet, Semmelweis Orvostudományi Egyetem I. GyermekklinikaHungary

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