Acta diabetologia latina

, Volume 19, Issue 2, pp 151–159 | Cite as

Serum lipid and lipoprotein levels and metabolic control in insulin-treated diabetics

  • Domenico Fedele
  • Giovannella Baggio
  • Renato Fellin
  • Fernanda De Romedi
  • Gaetano Crepaldi
  • Annunziata Lapolla
  • Francesco Frigato
Original Contributions
Received:

Summary

Serum lipid and lipoprotein levels were evaluated in 50 insulin-treated diabetic outpatients (25 male and 25 female) and in 46 normal volunteers (22 male and 24 female). In these groups metabolic evaluation was carried out by assaying fasting plasma glucose, glucose in urine and glycosylated hemoglobin (G-HbA1). No differences were observed in the lipid and lipoprotein patterns between diabetic patients and normals. HDL values were significantly lower in male subjects, diabetic and normal, as compared to females, but there were no differences between the diabetic and the normal group. G-HbA1 was significantly correlated to fasting plasma glucose and glucose in urine, but also to WS-TG and VLDL-TG. Fasting plasma glucose too was correlated to WS-TG and VLDL-TG. Moreover, a negative correlation was found between HDL-Ch and WS-TG and VLDL-TG. These results show that sufficiently well-controlled insulin-treated diabetics do not have altered plasma lipid and lipoprotein levels. In particular, in these patients HDL-Ch values can be normal, because insulin levels are sufficient to activate lipoprotein lipase and to guarantee an adequate plasma VLDL clearance.

Key-words

Glycosylated hemoglobin HDL-cholesterol Insulin-dependent diabetes Lipoproteins Serum lipids 
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Aleyassine H., Gardiner R. J., Tonks D. B., Koch P.: Glycosylated hemoglobin in diabetes mellitus: correlations with fasting plasma glucose, serum lipids and glycosuria — Diabetes Care3, 508, 1980.PubMedCrossRefGoogle Scholar
  2. 2.
    Ballantyne D., White C., Strevens E. A., Lawrie T. D. V., Lorimer A. R., Manderson W. G., Morgan H. G.: Lipoprotein concentrations in untreated adult onset diabetes mellitus and the relationship of the fasting plasma triglyceride concentrations to insulin secretion — Clin. chim. Acta78, 323, 1977.PubMedCrossRefGoogle Scholar
  3. 3.
    Balodimos M. C.: Diabetic nephropathy. In:Marble A., White P., Bradley R. F., Krall L. P. (Eds): Joslin’s Diabetes mellitus — 11th ed. Lea and Febiger, Philadelphia, 1971; p. 526.Google Scholar
  4. 4.
    Barr D. P., Russ E. M., Eder H. A.: Protein-lipid relationships in human plasma in atherosclerosis and related conditions — Amer. J. Med.11, 480, 1951.PubMedCrossRefGoogle Scholar
  5. 5.
    Beach K. W., Brunzell J. D., Conquest L. L., Strandness D. E.: The correlation of arteriosclerosis obliterans with lipoproteins in insulin-dependent and non-insulin-dependent diabetes — Diabetes28, 836, 1979.PubMedGoogle Scholar
  6. 6.
    Bercquist N.: Serum lipids in ambulatory diabetic clientele — Acta med. scand.187, 213, 1970.Google Scholar
  7. 7.
    Calvert G. D., Graham J. J., Mannik T., Wise P. H., Yeates R. A.: Effects of therapy on plasma-high-density-lipoprotein-cholesterol concentration in diabetes mellitus — Lancetii, 66, 1978.CrossRefGoogle Scholar
  8. 8.
    Daubresse J. C., Lemy C., Bailly A., Meunier J. C.: The usefulness of a rapid method for total fast hemoglobins determination in screening for diabetes control — Diabète Métab.5, 301, 1979.PubMedGoogle Scholar
  9. 9.
    Ditzel J., Nielsen N. V., Kjaergaard J.-J.: Hemoglobin Ak and red cell oxygen release capacity in relation to early retinal changes in newly discovered overt and chemical diabetics — Metabolism28 (Suppl. 1), 440, 1979.PubMedCrossRefGoogle Scholar
  10. 10.
    Dix D., Cohen P., Kingsley S., Lea M. J., Senkbell J., Sexton K.: Interference by lactescence in glycohemoglobin analysis — Clin. Chem.25, 494, 1979.PubMedGoogle Scholar
  11. 11.
    Dunn P. J., Cole R. A., Soeldner J. S., Gleason R. E., Kwa E., Firoozabadi H., Younger D., Graham C. A.: Temporal relationship of glycosylated hemoglobin concentrations to glucose control in diabetics — Diabetologia17, 213, 1979.PubMedCrossRefGoogle Scholar
  12. 12.
    Eckel R. H., Albers J. J., Cheung M. G., Wahl P. W., Lindgren F. T., Bierman E. L.: High density lipoprotein composition in insulin dependent diabetes mellitus — Diabetes30, 132, 1981.PubMedCrossRefGoogle Scholar
  13. 13.
    Elkeles R. S., Wu J., Hambley J.: Haemoglobin A1, blood glucose, and high-density lipoprotein cholesterol in insulin-requiring diabetes — Lancetii, 547, 1978.CrossRefGoogle Scholar
  14. 14.
    Fedele D., Fellin R., Lapolla A., Baggio G., Baiocchi M. R., Frigato F., Tiengo A.: Lipidi plasmatici e controllo metabolico della malattia diabetica. In:Erle G. (Ed.): Atti del Convegno: Emoglobina glicosilata e diabete mellito. La Grafica e Stampa, 1980; p. 121.Google Scholar
  15. 15.
    Fedele D., Lapolla A., Baldo G., Marescotti C., Tiengo A.: Glycosylated hemoglobin (G-Hb) in the endogenous hypertriglyceridemia — (Submitted for publication).Google Scholar
  16. 16.
    Ganda O. P.: Pathogenesis of macrovascular disease in the human diabetic — Diabetes29, 931, 1980.PubMedGoogle Scholar
  17. 17.
    Hankins W. D., Holladay L.: A temperature conversion nomogram for glycosylated hemoglobin analysis — Clin. chim. Acta104, 251, 1980.PubMedCrossRefGoogle Scholar
  18. 18.
    Hayes T. M.: Plasma lipoproteins in adult diabetes — Clin. Endocr.1, 247, 1972.PubMedGoogle Scholar
  19. 19.
    Howard B. V., Savage P. J., Bennion L. J., Bennett P. H.: Lipoprotein composition in diabetes mellitus — Atherosclerosis30, 153, 1978.PubMedCrossRefGoogle Scholar
  20. 20.
    Huggett A. S. F., Nixon D. A.: Use of glucose-oxidase, peroxidase and o-dianisine in the determination of blood and urine glucose — Lancetii, 368, 1957.CrossRefGoogle Scholar
  21. 21.
    Kaufmann R. L., Assal J. Ph., Soeldner J. S., Wilmshurst E. G., Lemaire J. R., Gleason R. E., White P.: Plasma lipid levels in diabetic children. Effect of diet restricted in cholesterol and saturated fats — Diabetes24, 672, 1975.PubMedCrossRefGoogle Scholar
  22. 22.
    Langberg R.: Diabetes mellitus mortality in the United States, 1950–1967 — Public Health Service Publication No. 1000, Series 20, No. 10. Washington, D.C., 1971.Google Scholar
  23. 23.
    Lipid Research Clinics Program: Manual of Laboratory Operations. Lipid and lipoprotein analysis.Gpodehw Publ. No. (NIH) 75-628, Washington, D.C., 1974; vol. 1, p. 56.Google Scholar
  24. 24.
    Lopes-Virella M. F. L., Stone P. G., Colwell J. A. Jr.: Serum high density lipoprotein in diabetic patients — Diabetologia13, 285, 1977.PubMedCrossRefGoogle Scholar
  25. 25.
    Mattock M. B., Fuller J. H., Maude P. S., Keen H.: Lipoproteins and plasma cholesterol esterification in normal and diabetic subjects — Atherosclerosis34, 437, 1979.PubMedCrossRefGoogle Scholar
  26. 26.
    Metropolitan Life Insurance Company: New weight standards for men and women — Stat. Bull. Metropol. Life Insur. Co.40, 1, 1959.Google Scholar
  27. 27.
    Nikkilä E.: Studies on the lipid-protein relationships in normal and pathologic sera and the effect of heparin on serum lipoproteins — Scand. J. clin. Lab. Invest. 5 (Suppl. 8) 158, 1953.PubMedGoogle Scholar
  28. 28.
    Nikkilä E. A., Hormila P.: Serum lipids and lipoproteins in insulin-treated adult diabetes. Demonstration of increased high density lipoprotein concentrations — Diabetes27, 1078, 1978.PubMedGoogle Scholar
  29. 29.
    Nikkilä E. A., Kekki M.: Plasma triglyceride transport kinetics in diabetes mellitus — Metabolism22, 1, 1973.PubMedCrossRefGoogle Scholar
  30. 30.
    Peterson C. M., Koenic R. J., Jones R. L., Saudek C. D., Cerami A.: Correlation of serum triglyceride levels and hemoglobin Ah concentrations in diabetes mellitus — Diabetes26, 507, 1977.PubMedCrossRefGoogle Scholar
  31. 31.
    Pietri A., Dunn F. L., Raskin P.: The effect of improved diabetic control on plasma lipid and lipoprotein levels. A comparison of conventional therapy in continuous subcutaneous insulin infusion — Diabetes29, 1001, 1980.PubMedCrossRefGoogle Scholar
  32. 32.
    Röschlau P., Bernt E., Gruber W.: Enzymatische Bestimmung des Gesamt-Cholesterins im Serum — Z. klin. Chem. klin. Biochem.12, 226, 1974.Google Scholar
  33. 33.
    Saudek C. D., Eder H. A.: Lipid metabolism in diabetes mellitus — Amer. J. Med.66, 843, 1979.PubMedCrossRefGoogle Scholar
  34. 34.
    Schaefer E. J., Levy R. I., Anderson D. W., Danner R. N., Brewer H. B. Jr., Blackwelder W. C.: Plasma triglycerides in regulation of HDL-cholesterol levels — Lancetii, 391, 1978.CrossRefGoogle Scholar
  35. 35.
    Schonfeld G., Birge C., Miller J. Ph., Kessler G., Santiago J.: Apolipoprotein B levels and altered lipoprotein composition in diabetes — Diabetes23, 827, 1974.PubMedGoogle Scholar
  36. 36.
    Seidel D. H., Wieland H., Ruppert C.: Improved techniques for assessment of plasma lipoprotein patterns. I. Precipitation in gel after electrophoresis with polyanionic compounds — Clin. Chem.19, 737, 1973.PubMedGoogle Scholar
  37. 37.
    Shafrir E.: Hyperlipidemia in diabetes. In:Sussman K. E., Metz R. J. S. (Eds): Diabetes mellitus diagnosis and treatment. 4th ed. American Diabetes Association, New York. 1975; p. 221.Google Scholar
  38. 38.
    Sommariva D., Scotti L., Massaroli C., Zanaboni L., Bonfiglioli D., Negrati M., Micossi P., Raggi U., Fasoli A.: Serum lipoproteins in diabetes: relation of alphalipoprotein level to therapy — Acta diabet. lat.17, 237, 1980.Google Scholar
  39. 39.
    Sosenko J. M., Breslow J. L., Miettinen O. S., Gabbay K. H.: Hyperglycemia and plasma lipid levels. A prospective study of young insulin-dependent diabetic patients — New Engl. J. Med.302, 650, 1980.PubMedCrossRefGoogle Scholar
  40. 40.
    Tamborlane W. V., Sherwin R. S., Genel M., Felig P.: Restoration of normal lipid and amino acid metabolism in diabetic patients treated with a portable insulin infusion pump — Lanceti, 1258, 1979.CrossRefGoogle Scholar
  41. 41.
    Taskinen M.-R., Nikkilä E. A.: Lipoprotein lipase activity of adipose tissue and skeletal muscle in insulin-deficient human diabetes. Relation to high-density and very-low density lipoproteins and response to treatment — Diabetologia17, 351, 1979.PubMedCrossRefGoogle Scholar
  42. 42.
    Wahlefeld A. W.: Triglyceride determination after enzymatic hydrolysis. In:Bergmeier H. U. (Ed.): Methoden der enzymatischen Analyse. III. Aufl. Verlag Chemie, Weinheim, 1974; vol. 2, p. 1878.Google Scholar
  43. 43.
    West K. M.: Epidemiology of diabetes and its vascular lesions. Elsevier, New York, 1978.Google Scholar
  44. 44.
    Wilson D. E., Schreibman P. H., Day V. C., Arky R. A.: Hyperlipidemia in an adult diabetic population — J. chron. Dis.23, 501, 1970.CrossRefGoogle Scholar

Copyright information

© Casa Editrice Il Ponte 1982

Authors and Affiliations

  • Domenico Fedele
    • 1
  • Giovannella Baggio
    • 1
  • Renato Fellin
    • 1
  • Fernanda De Romedi
    • 1
  • Gaetano Crepaldi
    • 1
  • Annunziata Lapolla
    • 1
  • Francesco Frigato
    • 1
  1. 1.Istituto di Medicina Clinica Divisione di Gerontologia e Malattie del RicambioUniversità di Padova PoliclinicoPadovaItaly

Personalised recommendations