Surgical treatment of renal cell carcinoma metastases: Prognostic significance
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Between January 1980 and March 1993, 166 patients with renal cell carcinoma were treated at Nagoya University Hospital. Among them 16 (9.6%) underwent surgical removal of 21 metastatic lesions: 12 patients had distant metastases at diagnosis and the other 4 demonstrated new distant metastases during their clinical course after nephrectomy. The metastatic lesions involved the brain in 6 patients, bone in 4, lung in 2, contralateral adrenal glands in 2, soft tissues in 2, lymph nodes in 2, pleura in 1, pancreas in 1, and contralateral renal pelvis in 1. All of the 16 patients underwent nephrectomy and 15 of them (93%) received interferon-α therapy. Patients with lesions which were completely resected had significantly longer survival than those with lesions which were palliatively treated and those with metastatic lesions at other sites (p=0.02). Improvement of performance status was observed in 5 of 6 (83%) patients undergoing palliative surgical treatment. The present study suggests that surgical removal of metastatic lesions prolongs survival in a limited number of renal cell carcinoma patients and that it improves performance status in those symptoms related to metastasis.
KeywordsRenal Cell Carcinoma Metastatic Lesion International Urology Metastatic Renal Cell Carcinoma Renal Cell Carcinoma Patient
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- 10.Hermanek, P., Sobin, L. H.: TNM Classification of Malignant Tumours. 4th ed. Springer-Verlag, Berlin 1987.Google Scholar
- 11.Skeel, R. T.: Systematic assessment of the patient with cancer. In: Skeel, R. T. (ed.). Handbook of Cancer Chemotherapy. 2nd ed. Little Brown, Boston 1987, pp. 15–24.Google Scholar
- 17.Takashi, M., Sakata, T., Nakano, Y., Nagai, T., Takaba, H., Tanaka, J., Okamura, K., Takamura, S., Kanai, S., Sahashi, M., Murase, T., Shimoji, T., Miyake, K.: Clinical characteristics and prognosis of renal cell carcinoma: Statistical evaluation of possible determinants for distant metastasis, venous tumor thrombi, and lymph node metastasis.Jpn. J. Urol., 83, 321 (1992).Google Scholar
- 20.Dreicer, R., Williams, R. D.: Renal parenchymal neoplasms. In: Tanagho, E. A., McAninch, J. W. (eds): Smith's General Urology. 13th ed. Appleton & Lange, Norwalk 1992, pp. 359–377.Google Scholar
- 22.Tanioka, F., Hiroi, M., Moriki, T., Yamashita, M., Yamane, T., Hara, H., Iijima, S.: Proliferating cell nuclear antigen (PCNA). Immunostaining in renal cell carcinoma and its relationship to tumor grading, flow cytometric DNA analysis and prognosis.GBK Fortbild. aktuel. Krebsdiagn. Therap., 62, 17 (1992).Google Scholar