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Journal of Neuro-Oncology

, Volume 5, Issue 2, pp 125–128 | Cite as

Corticosteroid toxicity in neuro-oncology patients

  • David E. Weissman
  • Denise Dufer
  • Victor Vogel
  • Martin D. Abeloff
Article

Summary

Hospital charts from 59 patients with intracranial malignancy or epidural spinal cord compression were reviewed to establish the frequency of clinically important corticosteroid toxicities and to determine treatment or patient characteristics which were predictive for toxicity. Thirty patients (51%) developed at least one steroid toxicity and eleven (19%) required hospital admission for diagnosis and/or management of steroid-related complications. In this retrospective analysis the duration of steroid therapy and the total administered dose predicted for toxicity. Patients with toxicity also had a significant fall in the serum albumin level. Important corticosteroid toxicity occurs frequently in neuro-oncology patients. Further research should be directed at developing non-toxic alternatives to corticosteroids.

Key words

corticosteroid brain metastases spinal metastases 

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References

  1. 1.
    Dukes MNG: Meyler's side effects of drugs. Excerpta Medica Amsterdam, Oxford, 1975, pp 812–840Google Scholar
  2. 2.
    Marshall LF, King J, Langfitt TW: The complications of high-dose corticosteroid therapy in neurosurgical patients: A prospective study. Ann Neurol 1:201–203, 1977PubMedCrossRefGoogle Scholar
  3. 3.
    Renaudin J, Fewer D, Wilson CB, Boldrey EB, Calogero J, Enot KJ: Dose dependency of Decadron in patients with partially excised brain tumors. J Neurosurg 39:302–305, 1977Google Scholar
  4. 4.
    Greenberg HS, Jim JH, Posner JB: Epidural spinal cord compression from metastatic tumor: Results with a new treatment protocol. Ann Neurol 8:361–366, 1980PubMedCrossRefGoogle Scholar
  5. 5.
    Slatkin NE, Posner JB: Management of spinal epidural metastases. Clin Neurosurg 3:698–716, 1982Google Scholar
  6. 6.
    Pezner RD, Lipsett JA. Peptic ulcer disease and other complications in patients receiving dexamethasone palliation for brain metastasis. West J Med 137:375–378, 1982PubMedGoogle Scholar
  7. 7.
    Martenson JA, Evans RG, Lie MR, Ilstrup DM, Dinapoli RP, Ebersold MJ, Earle JD: Treatment outcome and complications in patients treated for malignant epidural spinal cord compression (SCC). J Neurooncol, 3:77–84, 1985PubMedCrossRefGoogle Scholar
  8. 8.
    Warshaw AL, Welch JP, Ottinger LW: Acute perforation of the colon associated with chronic corticosteroid therapy. Am J Surg 131:442–446, 1976PubMedCrossRefGoogle Scholar
  9. 9.
    Butcher DL, Saha SA: Epidural lipomatosis: A complication of corticosteroid therapy. Ann Intern Med 90:60, 1979PubMedGoogle Scholar
  10. 10.
    The Boston Collaborative Drug Surveillance Program. Acute adverse reactions to prednisone in relation to dosage. Clin Pharmacol Ther 13:694–698, 1972Google Scholar
  11. 11.
    Lewis GP, Jusko WJ, Burke CW, Graves L: Prednisone side-effects and serum protein levels. Lancet 2:778–780, 1971PubMedCrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishers 1987

Authors and Affiliations

  • David E. Weissman
    • 1
  • Denise Dufer
    • 1
  • Victor Vogel
    • 1
  • Martin D. Abeloff
    • 1
  1. 1.The Johns Hopkins Oncology CenterThe Johns Hopkins HospitalBaltimoreUSA

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