Journal of Neuro-Oncology

, Volume 5, Issue 2, pp 125–128 | Cite as

Corticosteroid toxicity in neuro-oncology patients

  • David E. Weissman
  • Denise Dufer
  • Victor Vogel
  • Martin D. Abeloff


Hospital charts from 59 patients with intracranial malignancy or epidural spinal cord compression were reviewed to establish the frequency of clinically important corticosteroid toxicities and to determine treatment or patient characteristics which were predictive for toxicity. Thirty patients (51%) developed at least one steroid toxicity and eleven (19%) required hospital admission for diagnosis and/or management of steroid-related complications. In this retrospective analysis the duration of steroid therapy and the total administered dose predicted for toxicity. Patients with toxicity also had a significant fall in the serum albumin level. Important corticosteroid toxicity occurs frequently in neuro-oncology patients. Further research should be directed at developing non-toxic alternatives to corticosteroids.

Key words

corticosteroid brain metastases spinal metastases 


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Copyright information

© Martinus Nijhoff Publishers 1987

Authors and Affiliations

  • David E. Weissman
    • 1
  • Denise Dufer
    • 1
  • Victor Vogel
    • 1
  • Martin D. Abeloff
    • 1
  1. 1.The Johns Hopkins Oncology CenterThe Johns Hopkins HospitalBaltimoreUSA

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