Archiv für Gynäkologie

, Volume 217, Issue 2, pp 165–172 | Cite as

Fate of children born to women with jaundice in pregnancy

  • Anna -Karin Furhoff
Article

Abstract

The birthweights, the incidence of complications during delivery, and the present health are reported for 133 children of 58 women with jaundice during at least one pregnancy. The causes of jaundice were recurrent and non-recurrent cholestasis of pregnancy, and infectious hepatitis.

Deliveries complicated by jaundice and/or itching were associated with a lower birthweight (median 3170 g) than deliveries after entirely uncomplicated pregnancies (median 3450 g). Meconium staining of the amniotic fluid was found in 22% of deliveries with itching and/or jaundice, and in 9% of uncomplicated ones. Three children, whose mothers had jaundice during delivery, died from asphyxia. Itching or jaundice ending before delivery did not seem to have influenced the fate of the children. The findings were similar, whether the mothers had had recurrent or non-recurrent itching and/or jaundice, i.e. they were not primarily related to the cause of these symptoms, but to the period of pregnancy in which they appeared.

In general, itching or jaundice during pregnancy was not found to have influenced the children's future health.

Key words

Jaundice Pregnancy Birthweights Asphyxia 

Schicksal der Kinder von Frauen mit Ikterus in der Schwangerschaft

Zusammenfassung

Bericht über die Geburtsgewichte, die Häufigkeit komplizierter Geburten und der spätere Zustand von 133 Kindern von 58 Frauen mit Ikterus während mindestens einer Schwangerschaft. Ursachen des Ikterus waren rezidivierende und nicht-rezidivierende Schwangerschaftscholostase und infektiöse Hepatitis.

Entbindungen, die von Pruritus und/oder Ikterus kompliziert wurden, gingen einher mit einem niedrigeren Geburtsgewicht (Median 3170 g) als unkomplizierte Geburten (Median 3450 g). Mekoniumhaltiges Fruchtwasser wurde in 22% von Entbindungen mit Pruritus und/oder Ikterus und in 9% von unkomplizierten Entbindungen gefunden. Drei Kinder, deren Mütter Ikterus während der Entbindung hatten, starben an Asphyxie. Pruritus oder Ikterus, welcher vor der Entbindung aufhörte, scheint die Kinder nicht beeinflußt zu haben. Die Befunde waren unabhängig davon, ob die Mütter rezidivierenden oder nichtrezidivierenden Pruritus und/oder Ikterus gehabt hatten. Sie waren also nicht von der Ursache dieser Symptomen abhängig, sondern vom Stadium der Schwangerschaft, in dem diese vorkamen.

Im allgemeinen beeinflußt Pruritus oder Ikterus während der Schwangerschaft den zukünftigen Gesundheitszustand der Kinder nicht.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Adlercreutz, H., Tenhunen, R.: Some aspects of the interaction between natural and synthetic female sex hormones and the liver. Amer. J. Med.49, 630 (1970)PubMedCrossRefGoogle Scholar
  2. 2.
    Blanc, B., Lafon, M., Olmer, M., Piana, L., Sudan, J. P., Tronconi, J. C., Oliver, G.: Quatre observations d'ictère récidivant de la grossesse. Bull. Féd. Soc. Gynéc. Obstet. franç.21, 190 (1969)Google Scholar
  3. 3.
    Dippel, A. L.: Maligned umbilical cord entanglement. Amer. J. Obstet. Gynec.88, 1012 (1964)PubMedGoogle Scholar
  4. 4.
    Eliakim, M., Sadovsky, E., Stein, O., Shenkar, Y. G.: Recurrent cholestatic jaundice of pregnancy. Arch. intern. Med.117, 696 (1966)PubMedCrossRefGoogle Scholar
  5. 5.
    Engström, L., Sterky, G.: Standardkurvor för vikt och längd hos nyfödda barn. Läkartidn.63, 4922 (1966)Google Scholar
  6. 6.
    Fast, B. B., Roulston, T. M.: Idiopathic jaundice of pregnancy. Amer. J. Obstet. Gynec.88, 314 (1964)PubMedGoogle Scholar
  7. 7.
    Fisher, E. L.: Cord entanglement and fetal prognosis. Obstet. and Gynec.23, 608 (1964)Google Scholar
  8. 8.
    Friedlaender, P., Osler, M.: Icterus and pregnancy. Amer. J. Obstet. Gynec.97, 894 (1967)PubMedGoogle Scholar
  9. 9.
    Furhoff, A.-K.: Complications at delivery in women with jaundice in pregnancy. Arch. Gynäk.217, 155 (1974)Google Scholar
  10. 10.
    Furhoff, A.-K.: Itching in pregnancy. A follow-up study. (To be published)Google Scholar
  11. 11.
    Furhoff, A.-K., Hellström, K.: Jaundice in pregnancy. A follow-up study of the series of women originally reported by L. Thorling. I. The pregnancies. Acta med. scand.193, 259 (1973)PubMedCrossRefGoogle Scholar
  12. 12.
    Haemmerli, U. P.: Jaundice during pregnancy. Acta med. scand., Suppl. 444 (1966)Google Scholar
  13. 13.
    Ikonen, E.: Jaundice in late pregnancy. Acta obstet. gynec. scand.43 Suppl. 5 (1964)Google Scholar
  14. 14.
    Ingerslev, M., Teilum, G.: Jaundice during pregnancy. Acta obstet. gynec.31, 74 (1951)CrossRefGoogle Scholar
  15. 15.
    Leonard, J. L.: The significance of meconium-stained amniotic fluid in cephalic presentation. Obstet. and Gynec.20, 320 (1962)Google Scholar
  16. 16.
    Liebhart, M., Wójcicka, J.: Microscopic patterns of placenta in cases of pregnancy complicated by intrahepatic cholestasis (idiopathic jaundice). Pol. Med. J.9, 1589 (1970)PubMedGoogle Scholar
  17. 17.
    Matzkowski, H., Petzold, H., Bilek, K., Schlegel, C., Wohlgemuth, B.: Untersuchungen über den Ikterus in der Schwangerschaft. Z. ges. inn. Med.25, 729 (1970)PubMedGoogle Scholar
  18. 18.
    Oldershausen, H. F. von: Schwangerschaftsikterus und ovulationshemmende Steroide. Dtsch. med. J.19, 394 (1968)Google Scholar
  19. 19.
    Perreau, P., Rouchy, R.: Ictère cholostatique récidivant de la grossesse. Gynéc. et Obstét.60, 161 (1961)Google Scholar
  20. 20.
    Rencoret, R., Aste, H.: Jaundice during pregnancy. Med. J. Aust.1, 167 (1973)PubMedGoogle Scholar
  21. 21.
    Rendic, M.: Estudio de 24 casos de colestasis intrahepática del embarazo. Rev. chil. Obstet. Ginec.35, 50 (1970)Google Scholar
  22. 22.
    Roszkowski, I., Pisarek-Miedzińska, D.: Jaundice in pregnancy. II. Clinical course of pregnancy and delivery and condition of neonate. Amer. J. Obstet. Gynec.101, 500 (1968)PubMedGoogle Scholar
  23. 23.
    Sadovsky, E., Eliakim, M., Schenker, J. R.: Pruritus gravidarum of hepatic origin. Isr. J. med. Sci.6, 540 (1970)PubMedGoogle Scholar
  24. 24.
    Spellacy, W. N., Gravem, H., Fisch, R. O.: The umbilical cord complications of true knots, nuchal coils, and cords around the body. Amer. J. Obstet. Gynec.94, 1136 (1966)PubMedGoogle Scholar
  25. 25.
    Thiele, P., Sengebusch, W.-D., Dominok, G.: Internistische, gynäkologische und pathologisch-anatomische Kriterien des “idiopathischen Schwangerschaftsikterus”. 2 Teil. Dtsch. Gesundh.-Wes.24, 817 (1969)Google Scholar
  26. 26.
    Thorling, L.: Jaundice in pregnancy. Acta med. scand., Suppl. 302 (1955)Google Scholar

Copyright information

© J. F. Bergmann 1974

Authors and Affiliations

  • Anna -Karin Furhoff
    • 1
  1. 1.Department of MedicineKarolinska Institutet at SerafimerlasarettetStockholmSweden

Personalised recommendations