Clinical experience with cyanoacrylate tissue adhesive
In this paper 385 cases treated with cyanoacrylate tissue adhesive during the years 1980–1995 are studied. The indications, outcomes and complications of cyanoacrylate adhesive are investigated and the results are analysed.
It is encouraging that except for three cases of ocular hypotony and two cases of microbial infection no other complications occurred. Even in desperate cases with corneal perforation greater than 3 mm and ocular infection, enucleation was avoided. The early use of a bandage contact lens, inserted just after the glue application and the coverage with topical antibiotics switched every 15 days until the removal of the glue, may explain the small incidence of infection.
Our experience from the use of cyanoacrylate tissue adhesive in cases with corneal perforation greater than 3 mm is very encouraging. In these cases a running 10.0 nylon suture was used to create a reticulum over the space of the corneal perforation upon which the glue was applied. The use of cyanoacrylate tissue adhesive offers to the clinician a safe technique for healing corneal wounds that avoids tectonic penetrating keratoplasty with its associated complications.
Key wordscyanoacrylate adhesive tissue N-butyl cyanoacrylate corneal perforation bandage contact lens 10.0 silk suture glue
Unable to display preview. Download preview PDF.
- 1.Coover H, Jr, Joyner FB, Shearer NH, Jr, Wicker TH, Jr. Chemistry and performance of cyanoacrylate adhesives. SPE Tech Papers 1959; 5: 92.Google Scholar
- 2.Webster RG, Slansky HH, Refojo MF, Boruchoff SA, Dohlman CH. The use of adhesive for closure of corneal perforations. Arch Ophthalmol 1969, 80: 750.Google Scholar
- 3.Ellis RA, Levin AM. Experimental sutureless ocular surgery. Am J Ophthalmol 1963; 55: 733.Google Scholar
- 4.Droutsas D, Tsopelas N, Katri S. Le uso dei cyanocrylici in enorme perforatatione de la cornea. Congress de la Soc Ophthalmol Ital 1991.Google Scholar
- 6.Ginsberg SP, Pollack FM. Cyanoacrylate tissue adhesive in ocular disease. Ophthalmic Surg 1972; 3: 126.Google Scholar
- 7.Hirst LW, Smiddy WE, Stark WJ. Corneal perforations. Changing methods of treatment, 1960–1980. Ophthalmology 1982; 5: 630.Google Scholar
- 10.Refojo MF, Dohlman CH, Koliopoulos J. Adhesive in ophthalmology. A review. Surv Ophthalmol 1971; 15: 217.Google Scholar
- 11.Leyman RAW, West RL, Leonard F. Toxicity of alkyl 2-cyanoacrylates. II. Bacterial growth. Arch Surg 1966; 93: 447.Google Scholar
- 12.Page RC, Borick PM. Contamination and recovery of bacterial spores from methyl 2-cyanoacrylate monomer. Arch Surg 1967; 94: 162.Google Scholar
- 16.Martinez LA, Miller KN, Brown RH, Lynch MG. The Nd:Yag laser removal of cyanoacrylate used to repair conjunctival wound leaks. Amer J Ophthalmol 1987; 108: 86.Google Scholar