Documenta Ophthalmologica

, Volume 93, Issue 3, pp 237–245 | Cite as

Clinical experience with cyanoacrylate tissue adhesive

  • M. Moschos
  • D. Droutsas
  • P. Boussalis
  • G. Tsioulias
Article

Abstract

In this paper 385 cases treated with cyanoacrylate tissue adhesive during the years 1980–1995 are studied. The indications, outcomes and complications of cyanoacrylate adhesive are investigated and the results are analysed.

It is encouraging that except for three cases of ocular hypotony and two cases of microbial infection no other complications occurred. Even in desperate cases with corneal perforation greater than 3 mm and ocular infection, enucleation was avoided. The early use of a bandage contact lens, inserted just after the glue application and the coverage with topical antibiotics switched every 15 days until the removal of the glue, may explain the small incidence of infection.

Our experience from the use of cyanoacrylate tissue adhesive in cases with corneal perforation greater than 3 mm is very encouraging. In these cases a running 10.0 nylon suture was used to create a reticulum over the space of the corneal perforation upon which the glue was applied. The use of cyanoacrylate tissue adhesive offers to the clinician a safe technique for healing corneal wounds that avoids tectonic penetrating keratoplasty with its associated complications.

Key words

cyanoacrylate adhesive tissue N-butyl cyanoacrylate corneal perforation bandage contact lens 10.0 silk suture glue 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Coover H, Jr, Joyner FB, Shearer NH, Jr, Wicker TH, Jr. Chemistry and performance of cyanoacrylate adhesives. SPE Tech Papers 1959; 5: 92.Google Scholar
  2. 2.
    Webster RG, Slansky HH, Refojo MF, Boruchoff SA, Dohlman CH. The use of adhesive for closure of corneal perforations. Arch Ophthalmol 1969, 80: 750.Google Scholar
  3. 3.
    Ellis RA, Levin AM. Experimental sutureless ocular surgery. Am J Ophthalmol 1963; 55: 733.Google Scholar
  4. 4.
    Droutsas D, Tsopelas N, Katri S. Le uso dei cyanocrylici in enorme perforatatione de la cornea. Congress de la Soc Ophthalmol Ital 1991.Google Scholar
  5. 5.
    Hirst LW. de Juan E. Sodium hyalouronate and tissue adhesive in treating corneal perforations. Ophthalmology 1982; 89: 1250.PubMedGoogle Scholar
  6. 6.
    Ginsberg SP, Pollack FM. Cyanoacrylate tissue adhesive in ocular disease. Ophthalmic Surg 1972; 3: 126.Google Scholar
  7. 7.
    Hirst LW, Smiddy WE, Stark WJ. Corneal perforations. Changing methods of treatment, 1960–1980. Ophthalmology 1982; 5: 630.Google Scholar
  8. 8.
    Cavanaugh TB, Gottsch DJ. Infectious keratitis and cyanoacrylate adhesive. Am J Ophthalmol 1991; 111: 466.PubMedGoogle Scholar
  9. 9.
    Leahey BA, Gottsch DJ, Start JW. Clinical experience with N-butyl Cyanoacrylate (Nexactyl) tissue adhesive. Ophthalmology 1993; 100: 173.PubMedGoogle Scholar
  10. 10.
    Refojo MF, Dohlman CH, Koliopoulos J. Adhesive in ophthalmology. A review. Surv Ophthalmol 1971; 15: 217.Google Scholar
  11. 11.
    Leyman RAW, West RL, Leonard F. Toxicity of alkyl 2-cyanoacrylates. II. Bacterial growth. Arch Surg 1966; 93: 447.Google Scholar
  12. 12.
    Page RC, Borick PM. Contamination and recovery of bacterial spores from methyl 2-cyanoacrylate monomer. Arch Surg 1967; 94: 162.Google Scholar
  13. 13.
    Fogle JA, Kenyon KR, Foster CS. Tissue adhesive arrests stromal melting in the human cornea. Am J Ophthalmol 1980; 89: 795.PubMedGoogle Scholar
  14. 14.
    Golubovic S, Parunovic A. Cyanoacrylate glue in the treatment of corneal ulcerations. Fortschr Ophthalmol 1990; 87: 378.PubMedGoogle Scholar
  15. 15.
    Turss U, Turss R, Refojo MF. Removal of isobutyl cyanoacrylate adhesive from the cornea with acetone. Am J Ophthalmol 1970; 70: 725.PubMedGoogle Scholar
  16. 16.
    Martinez LA, Miller KN, Brown RH, Lynch MG. The Nd:Yag laser removal of cyanoacrylate used to repair conjunctival wound leaks. Amer J Ophthalmol 1987; 108: 86.Google Scholar

Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • M. Moschos
    • 1
  • D. Droutsas
    • 1
  • P. Boussalis
    • 1
  • G. Tsioulias
    • 1
  1. 1.Department of OphthalmologyUniversity of AthensGreece

Personalised recommendations