Calcified Tissue International

, Volume 46, Issue 5, pp 333–338 | Cite as

Inhibitory effect of fluoride on the secretion of insulin

  • A. Rigalli
  • J. C. Ballina
  • E. Roveri
  • R. C. Puche
Laboratory Investigations


The oral administration of sodium fluoride (NaF) (40 μmol/100 body weight [bw]) to fasting rats produced an immediate fall in insulin levels and the consequent increase in glycemia. These phenomena were observed with plasma fluoride concentrations 5–15 μM. Glycemia and insulin returned to normal levels within 4–5 hours, together with the washing out of fluoride from plasma and soft tissues. The insulin secretion of isolated Langerhans islets, perifused with solutions containing 5, 10, or 20 μM fluoride, was found to be significantly inhibited as a function of fluoride levels, both with basal and stimulatory concentrations of glucose. One hour after the intake of 60 mg of NaF, fasting human volunteers showed increased fluoride (5–15 μM) together with a significant fall of plasma insulin levels.

Key words

Fluoride Insulin Hormone (secretion) 


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Copyright information

© Springer-Verlag New York Inc 1990

Authors and Affiliations

  • A. Rigalli
    • 1
  • J. C. Ballina
    • 1
  • E. Roveri
    • 1
  • R. C. Puche
    • 1
  1. 1.Departamento de Ciencias, FisiológicasFacultad de Ciencias MédicasRosarioArgentina

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