Diabetes puts myocardial n-3 fatty acid status at risk in the absence of supplementation in the rat
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The changes in fatty acid incorporation into myocardial membranes that occurred with acute diabetes in this study were indicative of depressed PUFA desaturation. However this was largely confined to the long-chain n-3 PUFA, DHA. Anti-arrhythmic efficets of n-3 PUFA diets were associated with elevated DHA levels. It is conclused that perturbed PUFA metabolism in diabetes puts myocardial n-3 PUFA status at high risk which may have important implications for heart function and that this may be prevented by low-level supplementation with purified DHA.
polyunsaturated fatty acid
- 1.Fein, F.S. (1996) Clinical Manifestations of Diabetic Cardiomyopathy, in Chatham, J.C. Forder, J.R., and McNeill, J.H. (eds.)The Heart in Diabetes. (Kluwer, Dortrect, Netherlands).Developments in Cardiovascular Med. 185, 1–22.Google Scholar
- 4.McLennan, P.L. (1992) Relative Effects of Dietary Saturated Monounsaturated and Polyunsaturated Fatty Acids on Cardiac Arrhythmias in the Rat.Am. J. Clin. Nutr. 57, 207–212.Google Scholar