Calcified Tissue International

, Volume 49, Supplement 2, pp S9–S13 | Cite as

Use of calcitonin in the treatment of bone pain associated with osteoporosis

  • Carlo Gennari
  • Donato Agnusdei
  • Angelo Camporeale


In osteoporosis, calcitonin exerts an analgesic effect that is unrelated to its effect on bone. Although the precise mechanism has yet to be clarified, there is some evidence that the analgesic effect of calcitonin may be mediated through the endogenous opioid system. The intranasal administration of calcitonin seems to be more effective in producing analgesia than parenteral administration.

Key words

Analgesia Bone pain Calcitonin Intranasal administration Osteoporosis 


  1. 1.
    Melzach R, Wall PD (1965) Pain mechanisms: A new theory. Science 150:971–978CrossRefGoogle Scholar
  2. 2.
    Gennari C (1981) Calcitonin and bone metastases of cancer. In: Pecile A (ed) Calcitonin 1980. Excerpta Medica. Amsterdam, pp 277–287Google Scholar
  3. 3.
    Gennari C, Chierichetti SM, Gonnelli S, Vibelli C, Montagnani M, Piolini M (1986) Migraine prophylaxis with salmon calcitonin: A cross-over double blind placebo-controlled study. Headache 26:13–16PubMedCrossRefGoogle Scholar
  4. 4.
    Minaire P, Mallet E, Levernieux J, Schoutens A, Attali G, Caulin F (1987) Immobilization bone loss: Preventive effect of calcitonin in several clinical modules. In: Christiansen C et al (eds) Osteoporosis 1987. Osteopress, Copenhagen, p 603Google Scholar
  5. 5.
    Attali G, Levernieux J, Caulin F (1987) Recent crush fracture syndrome. Effect of salmon calcitonin. Results of three double blind studies and one open study. In: Christiansen C et al (eds) Osteoporosis 1987. Osteopress. Copenhagen, pp 930–932Google Scholar
  6. 6.
    Arinoviche R, Arriagada M, Jacobelli S, et al. (1987) Calcitonin in acute pain due to vertebral fractures in osteoporosis. Rev Med Chile 115:1039–1043PubMedGoogle Scholar
  7. 7.
    Levernieux J, Julien D, Caulin F (1986) The effect of calcitonin on bone pain and acute resorption related to recent osteoporotic crush fractures: Results of a double-blind and an open study. In: Cecchettin M et al (eds) Calciotropic Hormones and Calcium Metabolism. Elsevier, Amsterdam, pp 171–178Google Scholar
  8. 8.
    Bordier P, Kuntz D, Miravet L, Marie P (1979) Treatment of primary osteoporosis by the combination of salmon calcitonin, phosphorus and magnesium, Nouv Presse Med 8:444PubMedGoogle Scholar
  9. 9.
    Ringe JD, Welzel D (1987) Salmon calcitonin in the therapy of corticoid induced osteoporosis. Eur J Clin Pharm 33:35–39CrossRefGoogle Scholar
  10. 10.
    Gennari C (1983) Clinical aspects of calcitonin in pain. Triangle 22:157–163Google Scholar
  11. 11.
    Tschoipp FA, Henke H, Petermann JB, et al. (1985) Calcitonin gene-related peptide and its binding sites in the human central nervous system and pituitary. Proc Natl Acad Sci USA 92:248–252CrossRefGoogle Scholar
  12. 12.
    Laurian L, Oberman Z, Graf E, Gilad S, Hoerer E, Simantov R (1986) Calcitonin induced increase in ACTH, β-endorphin and cortisol secretion. Horm Metabol Res 18:268–271CrossRefGoogle Scholar
  13. 13.
    Gennari C, Agnusdei D, Gonnelli S, et al. (1990), Confirmation of the analgesic efficacy of Miacalcic nasal in the treatment of postmenopausal osteoporosis. In: Peck WA (ed) Prevention of Postmenopausal Osteoporosis, Dream or Reality?Parthenon Publishing, Carnforth, pp 65–74Google Scholar
  14. 14.
    Pun KK, Chan LWL (1989) Analgesic effect of intranasal salmon calcitonin in the treatment of osteoporotic vertebral fractures. Clin Ther 11:205–209PubMedGoogle Scholar
  15. 15.
    Pontiroli AE, Alberetto M, Calderara A, et al. (1986) Human calcitonin administered by the nasal route: Bioavailability of different formulations and efficacy in postmenopausal osteoporosis. Life Sci 125:249–253Google Scholar
  16. 16.
    Gennari C, Agnusdei D, Gonnelli S, et al. (1990) Bone pain in osteoporosis. In: Nordin BEC (ed) Osteoporosis Contribution to Modern Management. Parthenon Publishing, Carnforth, pp 57–64Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1991

Authors and Affiliations

  • Carlo Gennari
    • 1
  • Donato Agnusdei
    • 1
  • Angelo Camporeale
    • 1
  1. 1.Institute of Internal MedicineUniversity of SienaItaly

Personalised recommendations