Calcified Tissue International

, Volume 38, Issue 1, pp 62–65 | Cite as

Effects of ovariectomy on vertebral trabecular bone in the cynomolgus monkey (Macaca fascicularis)

  • L. C. Miller
  • D. S. Weaver
  • J. A. McAlister
  • D. R. Koritnik
Rapid Communications


Seventeen ovariectomized and twenty-one intact female cynomolgus macaques were examined for differences in vertebral trabecular bone volume. The ovariectomized group exhibited significantly less trabecular bone than the intact group (p<.005), 22 months post-ovariectomy. This finding encourages the use of the cynomolgus monkey as a model for the mechanism of bone loss in ovariectomy or postmenopausal osteoporosis.

Key words

Bone histomorphometry Macaca fascicularis Postmenopausal osteoporosis 


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  1. 1.
    Raisz, L.G.: Osteoporosis. J. Am. Geriatr. Soc. 30: 127–38, 1982.PubMedGoogle Scholar
  2. 2.
    Cann, C. E., Genant, H. K., Ettinger, B., and Gordan, G.S.: Spinal mineral loss in oophorectomized women. J. Am. Med. Assoc. 244 (18): 2056–2059, 1980.CrossRefGoogle Scholar
  3. 3.
    NIH: Osteoporosis. NIH Consensus Conference Statement 5 (3): 1984.Google Scholar
  4. 4.
    Bowen, W.H., and Koch, G. Determination of age in monkeys (Macaca irus) on the basis of dental development. Lab Animals 4: 113–123, 1970.Google Scholar
  5. 5.
    Adams, M.R., Clarkson, T.B., Kaplan, J.R., and Koritnik, D.R. Ovariectomy, social status and coronary artery atherosclerosis in cynomolgus monkeys. Arteriosclerosis 5(2): 192–200, 1985.PubMedGoogle Scholar
  6. 6.
    Cronin, M.J., and Koritnik, D.R. Dopamine receptors of the monkey anterior pituitary in various endocrine states. Endocrinology 112: 618–623, 1983.PubMedCrossRefGoogle Scholar
  7. 7.
    Hodgen, G.D., Goodman, A.L., O'Connor, A., and Johnson, D.K. Menopause in rhesus monkeys: Model for study of disorders in the human climacteric. Am. J. Obstet.-Gynecol. 127 (6): 581–584, 1977.PubMedGoogle Scholar
  8. 8.
    Parfitt, A.M. The physiologic and clinical significance of bone histomorphometric data. In: Bone Histomorphometry: Techniques and Interpretation. R.R. Recker, ed. CRC Press, Boca Raton, pp. 143–224, 1983.Google Scholar
  9. 9.
    Schock, C.C., Noyes, F.R., and Villanueva, A.R. Measurement of Haversian bone remodeling by means of tetracycline labeling in rib of rhesus monkeys. Henry Ford Hosp. Med. Bull 20: 131–144, 1972.Google Scholar
  10. 10.
    Cann, C.E., Genant, H.K., and Young, D.R. Comparison of vertebral and peripheral mineral losses in disuse osteoporosis in monkeys. Radiology 134: 525–529, 1980.PubMedGoogle Scholar
  11. 11.
    Bowles, E.A., Weaver, D.S., Tewelski, A.H., Wakefield, M.J., and Miller, L.C. Bone measurement by enhanced contrast image analysis: Ovariectomized and intactMacaca fascicularis as a model for human postmenopausal osteoporosis. Am. J. Phys. Anthrop. 67 (2): 99–103, 1985.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • L. C. Miller
    • 1
    • 2
  • D. S. Weaver
    • 1
    • 2
  • J. A. McAlister
    • 3
  • D. R. Koritnik
    • 1
  1. 1.Department of Comparative Medicine, Bowman Gray School of MedicineWake Forest UniversityWinston-Salem
  2. 2.Department of AnthropologyWake Forest UniversityWinston-Salem
  3. 3.The Bone Metabolic LaboratoryThe Orthopaedic HospitalCharlotte

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