Effects of ovariectomy on vertebral trabecular bone in the cynomolgus monkey (Macaca fascicularis)
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Seventeen ovariectomized and twenty-one intact female cynomolgus macaques were examined for differences in vertebral trabecular bone volume. The ovariectomized group exhibited significantly less trabecular bone than the intact group (p<.005), 22 months post-ovariectomy. This finding encourages the use of the cynomolgus monkey as a model for the mechanism of bone loss in ovariectomy or postmenopausal osteoporosis.
Key wordsBone histomorphometry Macaca fascicularis Postmenopausal osteoporosis
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