Calcified Tissue International

, Volume 38, Issue 1, pp 62–65 | Cite as

Effects of ovariectomy on vertebral trabecular bone in the cynomolgus monkey (Macaca fascicularis)

  • L. C. Miller
  • D. S. Weaver
  • J. A. McAlister
  • D. R. Koritnik
Rapid Communications

Summary

Seventeen ovariectomized and twenty-one intact female cynomolgus macaques were examined for differences in vertebral trabecular bone volume. The ovariectomized group exhibited significantly less trabecular bone than the intact group (p<.005), 22 months post-ovariectomy. This finding encourages the use of the cynomolgus monkey as a model for the mechanism of bone loss in ovariectomy or postmenopausal osteoporosis.

Key words

Bone histomorphometry Macaca fascicularis Postmenopausal osteoporosis 

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • L. C. Miller
    • 1
    • 2
  • D. S. Weaver
    • 1
    • 2
  • J. A. McAlister
    • 3
  • D. R. Koritnik
    • 1
  1. 1.Department of Comparative Medicine, Bowman Gray School of MedicineWake Forest UniversityWinston-Salem
  2. 2.Department of AnthropologyWake Forest UniversityWinston-Salem
  3. 3.The Bone Metabolic LaboratoryThe Orthopaedic HospitalCharlotte

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