Calcified Tissue International

, Volume 41, Issue 5, pp 259–261 | Cite as

Spinal bone mineral after 5 weeks of bed rest

  • Adrian LeBlanc
  • Victor Schneider
  • Jean Krebs
  • Harlan Evans
  • Satish Jhingran
  • Phillip Johnson
Clinical Investigations

Summary

Patients put at bedrest for medical reasons lose 1–2% of spinal bone mineral per week. Losses of this magnitude during even shortterm space flights of a few months would pose a serious limitation and require countermeasures. The spinal bone mineral (L2–L4) was determined in 6 healthy males (precision=2%) before and after 5 weeks of complete bed rest. Only one individual had a significant loss (3%) and the −0.9% mean change for the 6, was not significant (P=0.06). The average negative clacium balance during the 5 weeks was 4 g or 0.36% of total body calcium, similar to that reported in other bed-rest studies. Spinal bone loss, however, in healthy bed-rested males is significantly less than reported for bed-rested patients, suggesting that a large loss of spinal bone mineral does not occur during space flight missions lasting 5 weeks or less.

Key words

Bone mineral Spine Bed rest Calcium balance 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Lutwak L, Whedon GD, Lachance PA, Reid JM, Lipscomb HS (1969) Mineral electrolyte and nitrogen balance studies of the Gemini-VII fourteen day orbital space flight. J Clin Endocrinol Metab 29:1140–1156PubMedCrossRefGoogle Scholar
  2. 2.
    Stupakov GP, Kaseykin VS, Kolovskiy AP, Korolev VV (1984) Evaluation of changes in human axial skeletal bone structure during long-term spaceflights. Moscow Kosmicheskaya Biologiya I Aviakosmicheskaya Meditsina 18:33–37Google Scholar
  3. 3.
    Rambaut PC, Leach CS, Whedon GD (1979) A study of metabolic balance in crewmembers of Skylab IV. Acta Astronautica 6:1313–1322PubMedCrossRefGoogle Scholar
  4. 4.
    Rambaut PC, Johnston RS (1979) Prolonged weightlessness and calcium loss in man. Acta Astronautica 6:1113–1122PubMedCrossRefGoogle Scholar
  5. 5.
    Smith MC, Rambaut PC, Vogel JM, Whittle MW (1977) Bone mineral measurement—experiment M078. IN: Johnston RS, Dietlein LF (eds) Biomedical results from Skylab. US Government Printing Office, Washington, DC, NASA SP-377, pp. 183–190Google Scholar
  6. 6.
    Schneider VS, McDonald J (1984) Skeletal calcium homeostasis and countermeasures to prevent disuse osteoporosis. Calcif Tissue Int 36:S151-S154PubMedCrossRefGoogle Scholar
  7. 7.
    Krolner B, Toft B (1983) Vertebral bone loss: an unheeled side effect of therapeutic bed rest. Clin Sci 64:537–540PubMedGoogle Scholar
  8. 8.
    Hansson TH, Roos BO, Nachemson A (1975) Development of osteopenia in the fourth lumbar vertebra during prolonged bed rest after operation for scoliosis. Acta Orthop Scan 46:621–630CrossRefGoogle Scholar
  9. 9.
    Schneider VS (1981) Modification of negative calcium balance and bone mineral loss during prolonged bed rest. In: NASA Terminal Report, No. T-660-1981, Vol 1–3Google Scholar
  10. 10.
    Donaldson CL, Hulley SB, Vogel JM, Hattner RS, Bayers JH, McMillan DE (1970) Effect of prolonged bed rest on bone mineral. Metabolism 19:1071–1084PubMedCrossRefGoogle Scholar
  11. 11.
    LeBlanc AD, Evans HJ, Marsh C, Schneider VS, Johnson PC, Jhingran SG (1986) Precision of dual photon absorptiometry measurements. J Nucl Med 27:1362–1365PubMedGoogle Scholar
  12. 12.
    Ellis KJ, Cohn SH (1975) Correlation between skeletal calcium mass and muscle mass in man. J Appl Physiol 38:455–460PubMedGoogle Scholar
  13. 13.
    Deitrick JE, Whedon GD, Shorr E (1948) Effects of immobilization upon various metabolic and physiologic functions of normal men. Am J Med 4:3–36CrossRefPubMedGoogle Scholar
  14. 14.
    LeBlanc A, Marsh C, Evans H, Johnson P, Schneider V, Jhingran S (1985) Bone and muscle atrophy with suspension of the rat. J Appl Physiol 58:1669–1675PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • Adrian LeBlanc
    • 1
  • Victor Schneider
    • 2
  • Jean Krebs
    • 3
  • Harlan Evans
    • 3
  • Satish Jhingran
    • 1
  • Phillip Johnson
    • 3
  1. 1.Baylor College of MedicineHoustonUSA
  2. 2.University of Texas Health Sciences CenterHoustonUSA
  3. 3.Johnson Space CenterHoustonTexasUSA

Personalised recommendations