Dietary induction ofOsteitis Fibrosa Cystica in the rat: Roles of parathyroid hormone and calcitonin
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High phosphate diet which induces secondary hyperparathyroidism in adult intact rats cause severe nephrocalcinosis andosteitis fibrosa cystica. Removal of only the parathyroid gland, prevents the renal and skeletal damage. Transplantation of the parathyroid gland in the presence or absence of calcitonin prevents the bone lesions but not the kidney lesions. The data suggests that transplantation of the parathyroid gland impairs the ability of this gland to function normally under severe stimulation. Calcitonin has a protective action against nephrocalcinosis caused by a high phosphate diet only in the absence of endogenous parathyroid hormone. It is suggested that differences in skeletal and renal lesions may be the result of differences in the production or levels of the metabolites of vitamin D as consequence of variations in hormonal secretions and/or the circulating levels of calcium and phosphate.
KeywordsCalcitonin Parathyroid Hormone Parathyroid Gland Secondary Hyperparathyroidism Renal Lesion
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