Lipids

, Volume 24, Issue 11, pp 940–944

Fatty acid and β-amino acid syntheses in strains ofBacillus subtilis producing iturinic antibiotics

  • Marie-Laure Hourdou
  • Francoise Besson
  • Isabelle Tenoux
  • Georges Michel
Article

DOI: 10.1007/BF02544538

Cite this article as:
Hourdou, ML., Besson, F., Tenoux, I. et al. Lipids (1989) 24: 940. doi:10.1007/BF02544538

Abstract

Iturinic antibiotics, produced by different strains ofBacillus subtilis, contain long-chain β-amino acids (β-AA). The regulation of the synthesis of fatty acids (FA) and β-AA was studied by modifying the culture medium. Addition of possible precursors, branched-chain α-amino acids, to the medium affected the FA and β-AA compositions. According to this, theB. subtilis strains can be divided into two groups. The first contains the producers of mycosubtilin and bacillomycin F which synthesize a high level ofiso C16 chains; the second contains the producers of bacillomycin D, bacillomycin L and iturin which synthesize a high level ofn carbon chains.

The incorporation of radioactive sodium acetate into FA and β-AA showed rapid FA synthesis followed by a second synthetic step. Although the detailed mechanism has not yet been elucidated, this second step, corresponding to the β-AA synthesis, seemed to be a key step in determining the alkyl chain of β-AA.

Copyright information

© American Oil Chemists’ Society (AOCS) 1989

Authors and Affiliations

  • Marie-Laure Hourdou
    • 1
  • Francoise Besson
    • 1
  • Isabelle Tenoux
    • 1
  • Georges Michel
    • 1
  1. 1.Laboratoire de Biochimie MicrobienneURA (C.N.R.S.) 1176, Lyon IVilleurbanne CedexFrance

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