Antimotion effect of nooglutyl and its neuronal mechanism

  • V. V. Yasnetsov
  • V. A. Pravdivtsev
  • V. M. Popov
  • T. A. Voronina
  • N. M. Kiseleva
  • S. B. Kozlov
Pharmacology and Toxicology

Abstract

Experiments on rats demonstrate that nooglutyl exhibits pronounced vestibular-protective properties and by its antimotion activity does not rank below classic vestibular protectors, such as scopolamine and diprazine. Electrophysiological experiments on cats show that nooglutyl alters spontaneous activity in 80% of cortical neurons (somatosensory zone I and area 5 of the parietal association cortex) and considerably weakens effects caused by motion sickness: activation of single unit activity of somatosensory zone I and inhibition of neuron responses to somatic stimulation. This property of the preparation is believed to form the basis of its antimotion effect.

Key words

nooglutyl motion sickness cortical neurons 

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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • V. V. Yasnetsov
    • 1
  • V. A. Pravdivtsev
    • 1
  • V. M. Popov
    • 1
  • T. A. Voronina
    • 1
  • N. M. Kiseleva
    • 1
  • S. B. Kozlov
    • 1
  1. 1.Industrial Research Center GidrobiosMinistry of Health of RussiaMoscow

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