Molecular and General Genetics MGG

, Volume 104, Issue 3, pp 288–294 | Cite as

Polarised complementation at the pyrimidine-3 locus ofNeurospora

  • Alan Radford


A re-evaluation of complementation at the pyrimidine-3 locus ofNeurospora suggests the existence of polarity. This apparent polarity is supported by polar complementation of the majority of a number of mutants induced with the acridine ICR-170, and confirmed by the behavior of an allele which is shown by reversion studies to be a frameshift mutant.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Brockman, H. E., andF. J. de Serres: “Sorbose toxicity” inNeurospora. Amer. J. Bot.50, 709–714 (1964).CrossRefGoogle Scholar
  2. —, andW. Goben: Mutagenicity of a monofunctional alkylating derivative of acridine inNeurospora. Science 147, 750–751 (1965).PubMedCrossRefGoogle Scholar
  3. Davis, R. H.: An enzymatic difference amongpyr-3 mutants ofNeurospora. Proc. nat. Acad. Sci. (Wash.)46, 677–682 (1960).CrossRefGoogle Scholar
  4. Giles, N. H., M. E. Case, C. W. H. Partridge, andS. I. Ahmed: A gene cluster inNeurospora crassa coding for an aggregate of five aromatic synthetic enzymes. Proc. nat. Acad. Sci. (Wash.)58, 1930–1937 (1967).CrossRefGoogle Scholar
  5. Kapuler, A. M., andH. Bernstein: A molecular model for an enzyme based on a correlation between the genetic and complementation maps of the locus specifying the enzyme. J. molec. Biol.6, 443–451 (1963).CrossRefGoogle Scholar
  6. Malling, H. V., andF. J. de Serres: Relation between complementation patterns and genetic alterations in nitrous acid-inducedad-3 B mutants ofNeurospora crassa. Mutation Res.4, 425–440 (1967).PubMedGoogle Scholar
  7. Suyama, Y.: Genetic fine structure of thepyr-3 locus ofNeurospora crassa. Ph. D. Thesis, Kansas State University (1959).Google Scholar
  8. —,K. D. Munkres, andV. W. Woodward: Genetic analysis of thepyr-3 locus ofNeurospora crassa: the bearing of recombination and gene conversion upon interallelic linearity. Genetica30, 293–311 (1959).PubMedCrossRefGoogle Scholar
  9. Vogel, H.J.: Distribution of lysine pathways in fungi: evolutionary implications. Amer. Naturalist98, 435–446 (1964).CrossRefGoogle Scholar
  10. Webber, B. B.: Genetical and biochemical studies of histidine-requiring mutants ofNeurospora. Genetics 51, 263–273 (1965).PubMedGoogle Scholar
  11. Westergaard, M., andH. K. Mitchell:Neurospora V. A synthetic medium favoring sexual reproduction. Amer. J. Bot.34, 573–577 (1947).CrossRefGoogle Scholar
  12. Williams, L. G., andR. H. Davis: Genetic and physical relationship between two early steps of pyrimidine synthesis. Genetics60 238 (1968).Google Scholar
  13. Woodward, V. W.: Complementation and recombination amongpyr-3 heteroalleles ofNeurospora crassa. Proc. nat. Acad. Sci. (Wash.)48, 348–356 (1962).CrossRefGoogle Scholar
  14. —:J. R. de Zeeuw, andA. M. Srb: The separation and isolation of particular biochemical mutants of Neurospora by differential germination of conidia, followed by filtration and plating. Proc. nat. Acad. Sci. (Wash.)40, 192–200 (1954).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1969

Authors and Affiliations

  • Alan Radford
    • 1
  1. 1.Department of Biological SciencesStanford UniversityStanfordUSA

Personalised recommendations