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Dietary oligofructose lowers triglycerides, phospholipids and cholesterol in serum and very low density lipoproteins of rats

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Lipids

Abstract

The present study was aimed at answering the question why feeding rats an oligofructose (OFS) supplemented diet could cause a significant reduction in plasma lipid levels. Daily administration of a 10% (w/w) OFS-containing diet to normolipidemic male rats resulted in a decrease in plasma triglycerides, phospholipids and cholesterol. The triglyceride-lowering effect was observed after one week and lasted for at least 16 wk and was associated with a reduction in plasma very low density lipoproteins, indicating that the hypolipidemic effect of OFS may be due to changes in liver lipid metabolism. We therefore tested whether OFS feeding modified the capacity of the liver to synthesize triglycerides from free fatty acids. Hepatocytes isolated from livers of control and OFS-fed rats were incubated in the presence of [1-14C]palmitate, and both intracellular and extracellular [14C]triglyceride formation were quantified. We found that chronic feeding of an OFS-supplemented diet to rats significantly reduced the capacity of isolated hepatocytes to synthesize triglycerides from palmitate. The results suggest that, like other soluble dietary fibers, OFS significantly alters liver lipid metabolism, resulting over time in a significant reduction in plasma triglyceride, phospholipid and cholesterol levels.

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Abbreviations

ANOVA:

analysis of variance

BSA:

bovine serum albumin

HDL:

high-density lipoprotein

IDL:

intermediate density lipoprotein

LDL:

low-density lipoprotein

NDO:

nondigestible oligosaccharide

OFS:

oligofructose

SCFA:

short-chain fatty acids

SEM:

standard error of the mean

VLDL:

very low density lipoprotein

References

  1. Oku, T., Tokunaga, T., and Hosoya, N. (1984)J. Nutr. 114, 1574–1581.

    PubMed  CAS  Google Scholar 

  2. Rumessen, J.J., Bode, S., Hamberg, O., and Hoyer, E.G., (1990)Am. J. Clin. Nutr. 52, 675–681.

    PubMed  CAS  Google Scholar 

  3. Roberfroid, M. (1993)Critical Reviews in Food Science and Nutrition 33, 103–148.

    Article  PubMed  CAS  Google Scholar 

  4. Modler, H.W., McKellar, R.C., and Yaguchi, M. (1990)J. Inst. Can. Sci. Technol. Aliment. 23, 29–41.

    CAS  Google Scholar 

  5. Wang, X., and Gibson, G.R. (1993)Appl. Bacteriol. 75, 373–380.

    CAS  Google Scholar 

  6. Delzenne, N., Kok, N., Fiordaliso, M., Deboyser, D., Goethals, F., and Roberfroid, M. (1993)Am. J. Clin. Nutr. (suppl.) 57, 820S.

  7. Tokunaga, T., Oku, T., and Hosoya, N. (1986)J. Nutr. Sci. Vitaminol., 32, 111–121.

    PubMed  CAS  Google Scholar 

  8. Roberfroid, M., Gibson, G., and Delzenne, N. (1993)Nutr. Rev. 51, 137–146.

    Article  PubMed  CAS  Google Scholar 

  9. Berry, M.N., and Friend, D.S. (1969)J. Cell Biol. 43, 506–520.

    Article  PubMed  CAS  Google Scholar 

  10. Krack, G., Gravier, O., Roberfroid, M., and Mercier, M. (1980)Biochim. Biophys. Acta 632, 619–629.

    PubMed  CAS  Google Scholar 

  11. Capuzzi, D.M., Kackman, R.D., Uberti, M.M., and Ree, M.A. (1974)Biochem. Biophys. Res. Common. 60, 1499–1508.

    Article  CAS  Google Scholar 

  12. Deboyser, D., Goethals, F., Krack, G., and Roberfroid, M. (1989)Toxicol. Appl. Pharmacol. 97, 473–479.

    Article  PubMed  CAS  Google Scholar 

  13. Chapman, M.J., Goldstein, S., Lagrangeand, D., and Laplaud, M.P. (1981)J. Lipid Res. 22, 339–358.

    PubMed  CAS  Google Scholar 

  14. Ichara, K., and Shibasaki, Y. (1991)J. Lipid Res. 32, 1709–1712.

    Google Scholar 

  15. Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J. (1951)J. Biol. Chem. 193, 265–273.

    PubMed  CAS  Google Scholar 

  16. Fungwee, T.V., Cagen, L., Wilcox, H.G., and Heimberg, M. (1992)J. Lipid Res. 33, 179–191.

    Google Scholar 

  17. Groot, P.H.E., Scholte, H.R., and Hülsmann, W.C. (1976)Adv. Lipid Res. 14, 75–126.

    PubMed  CAS  Google Scholar 

  18. Tsuji, Y., Yamamada, K., Hosoya, N., and Moriuchi, S. (1986)J. Nutr. Sci. Vitaminol. 32, 93–100.

    PubMed  Google Scholar 

  19. Vigne, J.L., Lairon, D., Borel, P., Portugal, H., Pauli, A.M., Hauton, J.C., and Lafont, H. (1987)Br. J. Nutr. 58, 405–413.

    Article  PubMed  CAS  Google Scholar 

  20. Mazur, A., Gueux, E., Felgines, C., Bayle, D., Nassir, F., Demigné, C., and Rémésy, C. (1992)Proc. Soc. Exp. Biol. Med. 199, 345–350.

    PubMed  CAS  Google Scholar 

  21. Kasim, S.E., Leboeuf, R.C., Khilnani, S., Tallapaka, L., Dewunda, D., and Jen, D.K.L.C. (1992)J. Lipid Res. 33, 1–7.

    PubMed  CAS  Google Scholar 

  22. Demigné, C., Yacab, C., and Rémésy, C. (1986)J. Nutr. 116, 77–86.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Unité de Biochimie Toxicologique et Cancérologique, Département des Sciences Pharmaceutiques, Université Catholique de Louvain, 7369 Avenue Mounier, 73, B-1200, Brussels, Belgium

    Maria Fiordaliso, Nadine Kok, Fabienne Goethals, Dominique Deboyser, Marcel Roberfroid & Nathalie Delzenne

  2. Laboratoire de Pharmacothérapie, Faculté de Médecine, Université Catholique de Louvain, B-1200, Brussels, Belgium

    Jean-Pierre Desager

Authors
  1. Maria Fiordaliso
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  2. Nadine Kok
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  3. Jean-Pierre Desager
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  4. Fabienne Goethals
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  5. Dominique Deboyser
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  6. Marcel Roberfroid
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  7. Nathalie Delzenne
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Fiordaliso, M., Kok, N., Desager, JP. et al. Dietary oligofructose lowers triglycerides, phospholipids and cholesterol in serum and very low density lipoproteins of rats. Lipids 30, 163–167 (1995). https://doi.org/10.1007/BF02538270

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  • DOI: https://doi.org/10.1007/BF02538270

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