Lipids

, Volume 30, Issue 12, pp 1145–1150

Oxidative susceptibility of low density lipoprotein from rabbits fed atherogenic diets containing coconut, palm, or soybean oils

  • S. C. Yap
  • Y. M. Choo
  • N. F. Hew
  • S. F. Yap
  • H. T. Khor
  • A. S. H. Ong
  • S. H. Goh
Symposium

DOI: 10.1007/BF02536616

Cite this article as:
Yap, S.C., Choo, Y.M., Hew, N.F. et al. Lipids (1995) 30: 1145. doi:10.1007/BF02536616

Abstract

The oxidative susceptibilities of low density lipoproteins (LDL) isolated from rabbits fed high-fat atherogenic diets containing coconut, palm, or soybean oils were investigated. New Zealand white rabbits were fed atherogenic semisynthetic diets containing 0.5% cholesterol and either (i) 13% coconut oil and 2% corn oil (CNO), (ii) 15% refined, bleached, and deodorized palm olein (RBDPO), (iii) 15% crude palm olein (CPO), (iv) 15% soybean oil (SO), or (v) 15% refined, bleached, and deodorized palm olein without cholesterol supplementation [RBDPO(wc)], for a period of twelve weeks. Total fatty acid compositions of the plasma and LDL were found to be modulated (but not too drastically) by the nature of the dietary fats. Cholesterol supplementation significantly increased the plasma level of vitamin E and effectively altered the plasma composition of long-chain fatty acids in favor of increasing oleic acid. Oxidative susceptibilities of LDL samples were determined by Cu2+-catalyzed oxidation which provide the lag times and lag-phase slopes. The plasma LDL from all palm oil diets [RBDPO, CPO, and RBDPO(wc)] were shown to be equally resistant to the oxidation, and the LDL from SO-fed rabbits were most susceptible, followed by the LDL from the CNO-fed rabbits. These results reflect a relationship between the oxidative susceptibility of LDL due to a combination of the levels of polyun-saturated fatty acids and vitamin E.

Abbreviations

CNO

coconut oil with 13.3% corn oil

CPO

crude palm olein

LDL

low density lipoprotein

PUFA

polyunsaturated fatty acids

RBDPO

refined, bleached, and deodorized palm olein

RBDPO(wc)

refined, bleached, and deodorized palm olein without cholesterol supplementation

SO

soybean oil

α-TAc

α-tocopheryl acctate

VLDL

very low density lipoprotein

Copyright information

© American Oil Chemists’ Society 1995

Authors and Affiliations

  • S. C. Yap
    • 1
  • Y. M. Choo
    • 1
  • N. F. Hew
    • 2
  • S. F. Yap
    • 3
  • H. T. Khor
    • 4
  • A. S. H. Ong
    • 5
  • S. H. Goh
    • 2
  1. 1.Palm Oil Research Institute of MalaysiaUniversity of MalayaRuala LumpurMalaysia
  2. 2.Department of ChemistryUniversity of MalayaKuala LumpurMalaysia
  3. 3.Department of PathologyUniversity of MalayaKuala LumpurMalaysia
  4. 4.Department of BiochemistryUniversity of MalayaKuala LumpurMalaysia
  5. 5.Malaysian Palm Oil Promotion CouncilKuala LumpurMalaysia

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