Lipids

, Volume 27, Issue 11, pp 901–907

First year growth of preterm infants fed standard compared to marine oil n−3 supplemented formula

  • Susan E. Carlson
  • Richard J. Cooke
  • Susan H. Werkman
  • Elizabeth A. Tolley
Article

Abstract

Very low birth weight (VLBW) infants (748–1390 g, n=65) were randomly assigned to receive control or marine oil-supplemented formula when they achieved intakes >454 kJ (110 kcal)/kg/d of a formula designed for VLBW infants. Study formulas with or without marine oil were provided until 79 wk of postconceptional age (PCA), first in a formula designed for preterm infants followed by a formula designed for term infants. Infants were studied at regular intervals through 92 wk PCA. Weight, length, and head circumference were determined by standardized prodedures and normalized to the National Center for Health Statistics figures for growth of infants born at term of the same age and gender. Mean normalized weight, weight-to-length, and head circumference were greatest at 48 wk and decreased thereafter. The decline in normalized weight was greater in infants fed the marine oil-supplemented formula. Beginning at 40 wk, marine oil-supplemented infants compared to controls had significantly poorer Z-scores for weight, length and head circumference. In addition, birth order (negatively) and maternal height (positively) influenced weight and length achievement in infancy as shown previously in infants born at term.

Abbreviations

AGA

appropriate-for-gestational age

ANOVA

analysis of variance

BPD

bronchopulmonary dysplasia

DHA

docosahexaenoic acid

EPA

eicosapentaenoic acid

PCA

postconceptional age

SGA

small for gestational age

VLBW

very low birth weight

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References

  1. 1.
    Carlson, S.E., Rhodes, P.G., and Ferguson, M.G. (1986)Am. J. Clin. Nutr. 45, 798–804.Google Scholar
  2. 2.
    Carlson, S.E., Cooke, R.J., Rhodes, P.G., Peeples, J.M., Werkman, S.H. and Tolley, E.A. (1992)Pediatr. Res. 30, 404–412.Google Scholar
  3. 3.
    Neuringer, M., Connor, W.E., Van Petten, C., and Barstad, L. (1984)J. Clin. Invest. 73, 272–276.PubMedCrossRefGoogle Scholar
  4. 4.
    Bitman, J., Wood, L., Hamosh, M., Hamosh, P., and Mehta, N.R. (1983)Am. J. Clin. Nutr. 38, 300–312.PubMedGoogle Scholar
  5. 5.
    Innis, S.M. (1989) inDietary Omega-3 and Omega-6 Fatty Acids: Biological Effects and Nutritional Essentiality, NATO ASI Series, Series A. Life Sciences (Galli, C., and Simopoulos, A.P., eds.) Vol. 171, pp. 135–146, Plenum Press, New York.Google Scholar
  6. 6.
    Harris, W.S., Connor, W.E., and Lindsey, S. (1984)Am. J. Clin. Nutr. 40, 780–795.PubMedGoogle Scholar
  7. 7.
    Cunnane, S.C., McAdoo, K.R., and Horrobin, D.F. (1986)Br. J. Nutr. 56, 87–95.PubMedCrossRefGoogle Scholar
  8. 8.
    Clarke, S.D., Benjamin, L., Bell, L., and Phinney, S.D. (1988)Am. J. Clin. Nutr. 47, 828–835.PubMedGoogle Scholar
  9. 9.
    Dubowitz, L., Dubowitz, V., and Goldberg, C. (1970)J. Pediatr. 77, 1–10.PubMedCrossRefGoogle Scholar
  10. 10.
    Dibley, M.J., Goldsby, J.B., Staehling, N.W., and Trowbridge, F.L. (1987)Am. J. Clin. Nutr. 46, 5736–5748.Google Scholar
  11. 11.
    Hamill, P.V., Drizd, T.A., Johnson, C.L., Reed, R.B., Roche, A.S., and Moore, W.M. (1979)Am. J. Clin. Nutr. 32, 607–629.PubMedGoogle Scholar
  12. 12.
    Sokol, R.R., and Rohlf, F.J. (1981)Biometry, 2nd edn., pp. 232–262, W.H. Freeman, New York.Google Scholar
  13. 13.
    Wingerd, J. (1972)Hum. Biol. 42, 105–131.Google Scholar
  14. 14.
    SAS Institute Inc. (1985)User's Guide: Statistics Version, 5th edn., p. 956, SAS Institute, Inc., Cary.Google Scholar
  15. 15.
    Markestad, T., and Fitzhardinge, P.M. (1981)J. Pediatr. 98, 597–602.PubMedCrossRefGoogle Scholar
  16. 16.
    Suave, R.S., and Singhal, N. (1985)Pediatrics 76, 725–733.Google Scholar
  17. 17.
    Groothuis, J.R., and Rosenberg, A.A. (1987)Am. J. Dis. Child. 141, 992–995.PubMedGoogle Scholar
  18. 18.
    Karniski, W., Blair, C., and Vitucci, J.S. (1987)Am. J. Dis. Child. 141, 520–526.PubMedGoogle Scholar
  19. 19.
    Georgieff, M.K., Mills, M.M., Zempel, C.E., and Chang, P.N. (1989)J. Pediatr. 114, 288–292.PubMedCrossRefGoogle Scholar
  20. 20.
    Casey, P.H., Kraemer, H.D., Bernbaum, J., Tyson, J.E., Clifford Sells, J., Vogman, M.W., and Bauer, C.R. (1990)J. Pediatr. 117, 298–307.PubMedCrossRefGoogle Scholar
  21. 21.
    Carlson, S.E., Werkman, S.H., Peeples, J.M., Cooke, R.J., Tolley, E.A., and Wilson, W.M., III (1992) inEssential Fatty Acids and Eicosanoids: Proceedings of the Third International Congress (Gibson, R.A., and Sinclair, A.J., eds.) American Oil Chemists' Society, Champaign, pp. 192–196.Google Scholar

Copyright information

© American Oil Chemists’ Society 1992

Authors and Affiliations

  • Susan E. Carlson
    • 1
    • 2
    • 3
  • Richard J. Cooke
    • 1
    • 2
  • Susan H. Werkman
    • 1
    • 2
  • Elizabeth A. Tolley
    • 4
  1. 1.Department of Pediatrics, Newborn CenterUniversity of TennesseeMemphis
  2. 2.Department of Obstetrics and Gynecology, Newborn CenterUniversity of TennesseeMemphis
  3. 3.Department of Biochemistry, Newborn CenterUniversity of TennesseeMemphis
  4. 4.Department of Biostatistics and Epidemiology, Newborn CenterUniversity of TennesseeMemphis

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