First year growth of preterm infants fed standard compared to marine oil n−3 supplemented formula
- 164 Downloads
Very low birth weight (VLBW) infants (748–1390 g, n=65) were randomly assigned to receive control or marine oil-supplemented formula when they achieved intakes >454 kJ (110 kcal)/kg/d of a formula designed for VLBW infants. Study formulas with or without marine oil were provided until 79 wk of postconceptional age (PCA), first in a formula designed for preterm infants followed by a formula designed for term infants. Infants were studied at regular intervals through 92 wk PCA. Weight, length, and head circumference were determined by standardized prodedures and normalized to the National Center for Health Statistics figures for growth of infants born at term of the same age and gender. Mean normalized weight, weight-to-length, and head circumference were greatest at 48 wk and decreased thereafter. The decline in normalized weight was greater in infants fed the marine oil-supplemented formula. Beginning at 40 wk, marine oil-supplemented infants compared to controls had significantly poorer Z-scores for weight, length and head circumference. In addition, birth order (negatively) and maternal height (positively) influenced weight and length achievement in infancy as shown previously in infants born at term.
analysis of variance
small for gestational age
very low birth weight
Unable to display preview. Download preview PDF.
- 1.Carlson, S.E., Rhodes, P.G., and Ferguson, M.G. (1986)Am. J. Clin. Nutr. 45, 798–804.Google Scholar
- 2.Carlson, S.E., Cooke, R.J., Rhodes, P.G., Peeples, J.M., Werkman, S.H. and Tolley, E.A. (1992)Pediatr. Res. 30, 404–412.Google Scholar
- 5.Innis, S.M. (1989) inDietary Omega-3 and Omega-6 Fatty Acids: Biological Effects and Nutritional Essentiality, NATO ASI Series, Series A. Life Sciences (Galli, C., and Simopoulos, A.P., eds.) Vol. 171, pp. 135–146, Plenum Press, New York.Google Scholar
- 10.Dibley, M.J., Goldsby, J.B., Staehling, N.W., and Trowbridge, F.L. (1987)Am. J. Clin. Nutr. 46, 5736–5748.Google Scholar
- 12.Sokol, R.R., and Rohlf, F.J. (1981)Biometry, 2nd edn., pp. 232–262, W.H. Freeman, New York.Google Scholar
- 13.Wingerd, J. (1972)Hum. Biol. 42, 105–131.Google Scholar
- 14.SAS Institute Inc. (1985)User's Guide: Statistics Version, 5th edn., p. 956, SAS Institute, Inc., Cary.Google Scholar
- 16.Suave, R.S., and Singhal, N. (1985)Pediatrics 76, 725–733.Google Scholar
- 21.Carlson, S.E., Werkman, S.H., Peeples, J.M., Cooke, R.J., Tolley, E.A., and Wilson, W.M., III (1992) inEssential Fatty Acids and Eicosanoids: Proceedings of the Third International Congress (Gibson, R.A., and Sinclair, A.J., eds.) American Oil Chemists' Society, Champaign, pp. 192–196.Google Scholar