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Investigations of the origin of the furan fatty acids (F-acids)

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Lipids

Abstract

The possible role of linoleic acid as a biogenetic precursor of the furan fatty acids (F-acids) was investigated in in vivo experiments in the rat, using a C19 analogue of linoleic acid and gas chromatography-mass spectrometry. No evidence of incorporation of this compound into the F-acids was found. Using an improved analysis procedure by converting F-acids into their tetrahydrofuran derivatives (enabling a separation from the large amounts of normal fatty acids), F-acids (F3, F4 and F6) were detected in rat food, correcting earlier results.

Quantification of F-acid intake with food and excretion of furandicarboxylic acids in the urine, suggested the possibility that the F-acids are not produced de novo in the rat, but instead accumulate in tissue after nutritional intake.

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Abbreviations

GC:

gas chromatography

HPLC:

high performance liquid chromatography

MS:

mass spectrometry

TLC:

thin layer chromatography

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Authors and Affiliations

  1. National Chemical Research Laboratory, Council for Scientitic and Industrial Research, P.O. Box 395, 0001, Pretoria, Republic of South Africa

    Charles P. Gorst-Allman

  2. Lehrstuhl für Organische Chemie I der Universität Bayreuth, Universitätsstrasse 30, Postfach 10 12 51, De8580, Bayreuth, Federal Republic of Germany

    Volker Puchta & G. Spiteller

Authors
  1. Charles P. Gorst-Allman
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  2. Volker Puchta
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  3. G. Spiteller
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Gorst-Allman, C.P., Puchta, V. & Spiteller, G. Investigations of the origin of the furan fatty acids (F-acids). Lipids 23, 1032–1036 (1988). https://doi.org/10.1007/BF02535648

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  • DOI: https://doi.org/10.1007/BF02535648

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