Skip to main content
SpringerLink
Log in

The binding of micellar lipids to chitosan

  • Published:
Lipids

Abstract

The lipid binding capacity of chitosan (partially deacetylated chitin) was determinined with respect to micellar solutions of bile salts, dodecyl sulfate, natural ox bile and an artificial mixed microemulsion. The stoichiometry was determined following the separation of the solid phase by filtration or centrifugation. The major variables in the extent of binding were the pH and ionic strength, suggesting that the interactions are mainly of ionic nature. It is noteworthy that under optimal conditions chitosan could bind, i.e., coprecipitate, with 4–5 times of its weight with all the lipid aggregates tested. These results have a bearing on the nutritional and pharmacological applications of chitosan. The analyses of the components from the precipitates with microemulsion and ox bile show a significant selectivily of binding caused by hydrophobic interactions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Muzzarelli, R.A.A. (1977) Chitin, Pergamon Press, New York.

    Google Scholar 

  2. Yoshida, T., and Yamashita, H. (1975) Japan 136, 287.

    Google Scholar 

  3. Sugano, M., Fujikawa, T., Hiratsuji, Y., and Hasegawa, Y. (1978) Nutr. Rept. Int. 18, 531–537.

    CAS  Google Scholar 

  4. Nagyvary, J.J., Falk, J.D., Hill, M.L. Schmidt, M.L., Wilkins, A.K., and Bradbury, E.L. (1979) Nutr. Rep. Int. 10, 677–684.

    Google Scholar 

  5. Knorr, D.J. (1982) Food Sci. 47, 593–595.

    Article  CAS  Google Scholar 

  6. Landes, D.R., and Bough, W.A. (1976) Bull. Environ. Contam. Toxicol. 15, 555–563.

    Article  PubMed  CAS  Google Scholar 

  7. Furda, I. (1980) Nonabsorbable Lipid Binder, U.S. Patent 4,223,023.

  8. Singleton, W.S., Gray, M.S., Brown, M.L., and White, J.L. (1965) J. Am. Oil Chem. Soc. 42, 53–56

    PubMed  CAS  Google Scholar 

  9. Irvin, J.L., Johnston, C.G., and Kopala, J. (1944) J. Biol. Chem. 153, 439–457.

    CAS  Google Scholar 

  10. Hofmann, A.F., and Borgstrom, B. (1964) J. Clin. Invest. 43, 247–257.

    PubMed  CAS  Google Scholar 

  11. Borgstrom, B., Dahlquist, A., Lundh, G., and Sjovall, J. (1957) J. Clin. Invest. 36, 1521–1536.

    Article  PubMed  CAS  Google Scholar 

  12. Falk, J.D., and Nagyvary, J.J. (1982) J. Nutr. 112, 182–188.

    PubMed  CAS  Google Scholar 

  13. Vahouny, G.V., Tombes, R., Cassidy, M.M., Kritchevsky, D., and Gallo, L.L. (1980) Lipids 15, 1012–1018.

    Article  PubMed  CAS  Google Scholar 

  14. Sugano, M., Fujikawa, T., Hiratsuji, Y., Nakashima, K., Fukuda, N., and Hasegawa, Y. (1980) Am. J. Clin. Nutr. 33, 787–793.

    PubMed  CAS  Google Scholar 

Download references

Author information

Author notes

  1. J. L. Nauss

    Present address: 95th Chem. Co. APO, U.S. Army, 09169, NY

Authors and Affiliations

  1. Department of Biochemistry & Biophysics, Taxas A&M University, 77843, College Station, TX

    J. L. Nauss, J. L. Thompson & J. Nagyvary

Authors
  1. J. L. Nauss
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. L. Thompson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Nagyvary
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Nauss, J.L., Thompson, J.L. & Nagyvary, J. The binding of micellar lipids to chitosan. Lipids 18, 714–719 (1983). https://doi.org/10.1007/BF02534538

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02534538

Keywords

Search

Navigation