, Volume 11, Issue 11, pp 781–790 | Cite as

Further studies of the saturated methyl branched fatty acids ofVernix caseosa lipid

  • N. Nicolaides
  • J. M. B. Apon
  • David H. Wong


By the method of capillary gas chromatography-mass spectrometry, we have identified 35 monomethyl and 46 dimethyl branched acids in the saturated acids of vernix caseosa lipid with chain lengths ranging from C11 to C18. Many other mono-, di-, and trimethyl branched acids have been partially identified. All methyl branches were found to be on the even numbered C-atoms except for some terminal iso methyl groups. Three types of dimethyl branched acids were found: those with a terminal iso structure, those with a terminal anteiso structure, and those with neither iso nor anteiso structures. The 4-methyl branch predominated for all types of branched acids. Equivalent chain length data for di- and trimethyl branched acids were determined on a Pentasil (nonpolar) wall coated capillary column and checked by calculation from monomethyl branched acid data. Mass spectral identification was performed with and without the aid of a data system. A possible mode of formation of these acids is discussed.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Nicolaides, N., Lipids 6:901 (1971).PubMedCrossRefGoogle Scholar
  2. 2.
    Nicolaides, N., and T. Ray, JAOCS 42:702 (1965).PubMedGoogle Scholar
  3. 3.
    Apon, J.M.B., and N. Nicolaides, J. Chrom. Sci. 13:467 (1975).Google Scholar
  4. 4.
    Vandenheuvel, F.A., Anal. Chem. 28:362 (1956).CrossRefGoogle Scholar
  5. 5.
    Nicolaides, N., and J.M.B. Apon, to be submitted to Biomedical Mass Spectrometry.Google Scholar
  6. 6.
    McCloskey, J.A., and J.H. Law, Lipids 2:225 (1967).CrossRefGoogle Scholar
  7. 7.
    Ryhage, R., and E. Stenhagen, Ark. Kemi. 15:219 (1960).Google Scholar
  8. 8.
    McCloskey, J.A., in “Topics in Lipid Chemistry,” Vol. I, Edited by F.D. Gunstone, Wiley-Intersciences, New York, NY, 1969, p. 369.Google Scholar
  9. 9.
    Karlsson, H., and G. Odham, Ark. Kemi. 31:143 (1969).Google Scholar
  10. 10.
    Jacob, J., and J. Poltz, J. Lipid Res. 15:243 (1974).PubMedGoogle Scholar
  11. 11.
    Nicolaides, N., Science 186:19 (1974).PubMedCrossRefGoogle Scholar

Copyright information

© American Oil Chemists’ Society 1976

Authors and Affiliations

  • N. Nicolaides
    • 1
  • J. M. B. Apon
    • 1
  • David H. Wong
    • 2
  1. 1.Department of Medicine Section of DermatologyUniversity of Southern California School of MedicineLos Angeles
  2. 2.Pharmaceutical Science CenterUniversity of Southern CaliforniaLos Angeles

Personalised recommendations