Lipids

, Volume 7, Issue 6, pp 426–429

On the rate of cholesterol esterification in cord blood serum

  • Andras G. Lacko
  • Harold L. Rutenberg
  • Louis A. Soloff
Article

Abstract

Cholesterol esterification was studied in adult and cord serum by measureing the initial rate of lecithin-cholesterol acyl transferase (LCAT) activity. Cord serum had about one-third as much free and esterified cholesterol and about one-half as much LCAT as adult serum. When the adult LCAT activities are plotted against the individual's serum free cholesterol levels a straight line relationship results (0.101±.005% cholesterol esterified per min). Cord serum LCAT activities (.135±.0407% cholesterol esterified per min) in the main fall above the adult line. Our results show that cord serum can esterify cholesterol at a rate equal to or higher than adult serum when the LCAT activity is related to the amount of serum free cholesterol present.

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Copyright information

© American Oil Chemists’ Society 1972

Authors and Affiliations

  • Andras G. Lacko
    • 1
  • Harold L. Rutenberg
    • 1
  • Louis A. Soloff
    • 1
  1. 1.Division of Cardiology, Department of Medicine and the Fels Research InstituteTemple University Health Sciences CenterPhiladelphia

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