Calcified Tissue International

, Volume 58, Issue 3, pp 133–134 | Cite as

Insulin-like growth factors and their role in osteoporosis

  • Ernesto Canalis
  • Donato Agnusdei
Clinical Investigations


Osteoporosis Metabolic Bone Disorder Skeletal Cell Skeletal Growth Factor Matrix Apposition Rate 
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  1. 1.
    Canalis E, Pash J, Varghese S (1993) Skeletal growth factors. Crit Rev Eukaryot Gene Express 3:155–166Google Scholar
  2. 2.
    Delany AM, Pash J, Canalis E (1994) Cellular and clinical perspectives on skeletal insulin-like growth factor I. J Cell Biochem 55:328–333PubMedCrossRefGoogle Scholar
  3. 3.
    Hammerman MR (1987) Insulin-like growth factors and aging. Endocinol Metab Clin North Am 16:995–1008Google Scholar
  4. 4.
    Romagnoli E, Minisola S, Carnevale V, Rosso R, Pacitti MT, Scarda A, Scarnecchia L, Mazzuoli G (1994) Circulating levels of insulin-like growth factor binding protein 3 (IGFBP-3) and insulin-like growth factor I (IGF-I) in perimenopausal women. Osteoporos Int 4:305–308PubMedCrossRefGoogle Scholar
  5. 5.
    Romagnoli E, Minisola S, Carnevale V, Scarda A, Rosso R, Scarnecchia L, Pacitti MT, Mazzuoli G (1993) Effect of estrogen deficiency on IGF-I plasma levels: relationship with bone mineral density in perimenopausal women. Calcif Tissue Int 53:1–6PubMedCrossRefGoogle Scholar
  6. 6.
    Nicolas V, Prewett A, Bettica P, Mohan S, Finkelman RD, Baylink DJ, Farley JR (1994) Age-related decreases in insulin-like growth factor-I and transforming growth factor-β in femoral cortical bone from both men and women: implications for bone loss with aging. J Clin Endocrinol Metab 78:1011–1016PubMedCrossRefGoogle Scholar
  7. 7.
    Delany AM, Dong Y, Canalis E (1994) Mechanisms of glucocorticoid action in bone cells. J Cell Biochem 56:295–302PubMedCrossRefGoogle Scholar
  8. 8.
    Canalis E (1992) Clinical review 35: growth factors and their potential clinical value. J Clin Endocrinol Metab 75:1–4PubMedCrossRefGoogle Scholar
  9. 9.
    Canalis E (1995) Growth hormone, skeletal growth factors and osteoporosis. Endocr Pract 1:39–43PubMedGoogle Scholar
  10. 10.
    Clemmons DR (1992) Editorial: role of insulin-like growth factor-I in reversing catabolism. J Clin Endocrinol Metab 75: 1183–1196PubMedCrossRefGoogle Scholar
  11. 11.
    Ebeling PR, Jones JD, O'Fallon WM, Janes CH, Riggs BL (1993) Short-term effects of recombinant human insulin-like growth factor-I on bone turnover in normal women. J Clin Endocrinol Metab 77:1384–1387PubMedCrossRefGoogle Scholar
  12. 12.
    Grinspoon SK, Baum HBA, Peterson S, Kilbanski A (1995) Effects of rhIGF-I administration on bone turnover during short-term fasting. J Clin Invest 96:900–906PubMedGoogle Scholar
  13. 13.
    Canalis E, Centrella M, Burch M, McCarthy TL (1989) Insulin-like growth factor I mediates selected anabolic effects of parathyroid hormone in bone cultures. J Clin Invest 83:60–65PubMedCrossRefGoogle Scholar
  14. 14.
    Finkelstein JS, Klibanski A, Schaefer EH, Hornstein MD, Schiff I, Neer RM (1994) Parathyroid hormone for the prevention of bone loss induced by estrogen deficiency. N Engl J Med 331:1618–1623PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1996

Authors and Affiliations

  • Ernesto Canalis
    • 1
    • 2
  • Donato Agnusdei
    • 3
  1. 1.St. Francis Hospial and Medical CenterHartfordUSA
  2. 2.The University School of MedicineFarmingtonUSA
  3. 3.Institute of Internal MedicineUniversity of Siena School of MedicineSienaItaly

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