Advertisement

Calcified Tissue International

, Volume 58, Issue 3, pp 133–134 | Cite as

Insulin-like growth factors and their role in osteoporosis

  • Ernesto Canalis
  • Donato Agnusdei
Clinical Investigations

Keywords

Osteoporosis Metabolic Bone Disorder Skeletal Cell Skeletal Growth Factor Matrix Apposition Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Canalis E, Pash J, Varghese S (1993) Skeletal growth factors. Crit Rev Eukaryot Gene Express 3:155–166Google Scholar
  2. 2.
    Delany AM, Pash J, Canalis E (1994) Cellular and clinical perspectives on skeletal insulin-like growth factor I. J Cell Biochem 55:328–333PubMedCrossRefGoogle Scholar
  3. 3.
    Hammerman MR (1987) Insulin-like growth factors and aging. Endocinol Metab Clin North Am 16:995–1008Google Scholar
  4. 4.
    Romagnoli E, Minisola S, Carnevale V, Rosso R, Pacitti MT, Scarda A, Scarnecchia L, Mazzuoli G (1994) Circulating levels of insulin-like growth factor binding protein 3 (IGFBP-3) and insulin-like growth factor I (IGF-I) in perimenopausal women. Osteoporos Int 4:305–308PubMedCrossRefGoogle Scholar
  5. 5.
    Romagnoli E, Minisola S, Carnevale V, Scarda A, Rosso R, Scarnecchia L, Pacitti MT, Mazzuoli G (1993) Effect of estrogen deficiency on IGF-I plasma levels: relationship with bone mineral density in perimenopausal women. Calcif Tissue Int 53:1–6PubMedCrossRefGoogle Scholar
  6. 6.
    Nicolas V, Prewett A, Bettica P, Mohan S, Finkelman RD, Baylink DJ, Farley JR (1994) Age-related decreases in insulin-like growth factor-I and transforming growth factor-β in femoral cortical bone from both men and women: implications for bone loss with aging. J Clin Endocrinol Metab 78:1011–1016PubMedCrossRefGoogle Scholar
  7. 7.
    Delany AM, Dong Y, Canalis E (1994) Mechanisms of glucocorticoid action in bone cells. J Cell Biochem 56:295–302PubMedCrossRefGoogle Scholar
  8. 8.
    Canalis E (1992) Clinical review 35: growth factors and their potential clinical value. J Clin Endocrinol Metab 75:1–4PubMedCrossRefGoogle Scholar
  9. 9.
    Canalis E (1995) Growth hormone, skeletal growth factors and osteoporosis. Endocr Pract 1:39–43PubMedGoogle Scholar
  10. 10.
    Clemmons DR (1992) Editorial: role of insulin-like growth factor-I in reversing catabolism. J Clin Endocrinol Metab 75: 1183–1196PubMedCrossRefGoogle Scholar
  11. 11.
    Ebeling PR, Jones JD, O'Fallon WM, Janes CH, Riggs BL (1993) Short-term effects of recombinant human insulin-like growth factor-I on bone turnover in normal women. J Clin Endocrinol Metab 77:1384–1387PubMedCrossRefGoogle Scholar
  12. 12.
    Grinspoon SK, Baum HBA, Peterson S, Kilbanski A (1995) Effects of rhIGF-I administration on bone turnover during short-term fasting. J Clin Invest 96:900–906PubMedGoogle Scholar
  13. 13.
    Canalis E, Centrella M, Burch M, McCarthy TL (1989) Insulin-like growth factor I mediates selected anabolic effects of parathyroid hormone in bone cultures. J Clin Invest 83:60–65PubMedCrossRefGoogle Scholar
  14. 14.
    Finkelstein JS, Klibanski A, Schaefer EH, Hornstein MD, Schiff I, Neer RM (1994) Parathyroid hormone for the prevention of bone loss induced by estrogen deficiency. N Engl J Med 331:1618–1623PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1996

Authors and Affiliations

  • Ernesto Canalis
    • 1
    • 2
  • Donato Agnusdei
    • 3
  1. 1.St. Francis Hospial and Medical CenterHartfordUSA
  2. 2.The University School of MedicineFarmingtonUSA
  3. 3.Institute of Internal MedicineUniversity of Siena School of MedicineSienaItaly

Personalised recommendations