Annals of Surgical Oncology

, Volume 7, Issue 3, pp 199–203 | Cite as

Pleural extension of mucinous tumor in patients with pseudomyxoma peritonei syndrome

  • Sophie R. Pestieau
  • Jesus Esquivel
  • Paul H. Sugarbaker
Article

Abstract

Background

Pseudomyxoma peritonei syndrome is a rare disease arising from perforation of an adenoma of the appendix. The syndrome is characterized by progressive accumulation of mucinous fluid and tumor within the abdomen and pelvis. Although this tumor is only superficially invasive and does not metastasize, it is a fatal disease. Extra-abdominal spread of pseudomyxoma peritonei is a rare occurrence, with few reports in the medical literature. This review focuses on pleural extension of mucinous tumor in patients with pseudomyxoma peritonei syndrome.

Methods

From December 1983 to April 1999, all patients who underwent cytoreductive surgery for pseudomyxoma peritonei syndrome were assessed for pleural involvement at the time of the presentation or follow-up. Clinical information on these patients, including chest computed tomographic scan, was retrospectively reviewed. The mechanisms of extension of mucinous tumor from peritoneal cavity to pleural surface and the results of treatment were of special interest.

Results

Twenty-three of 426 patients (5.4%) showed pleural extension of pseudomyxoma peritonei syndrome. In four patients (17%), extension into the chest occurred before cytoreductive surgery. In 18 patients, the pleural space was entered during a subdiaphragmatic peritonectomy; and, in 12 patients, extension of disease from peritoneal to pleural space occurred. In six patients (26%), surgical interventions were required to excise tumor that had invaded the hemidiaphragm; and, in the six other patients (26%), there was a minor penetration during subphrenic peritonectomy, which was closed immediately. Finally, in seven patients (30%), the mechanism of spread was unknown. Twelve patients were treated for pleural thoracotomy. Eight patients had an attempt to completely eradicate pleural mucinous tumor, and five patients are currently disease free in the chest (22%); four of these five had intrapleural cytoreduction plus intrapleural chemotherapy. The median survival for all 23 patients is 55 months.

Conclusion

Pleural spread of pseudomyxoma peritonei syndrome may be a direct result of cytoreductive surgery and the subphrenic peritonectomy procedure. In some patients, dissecting mucinous tumor may infiltrate through the diaphragm and result in pleural extension. Pleural extension of pseudomyxoma peritonei syndrome carries a poor prognosis. Intrapleural chemotherapy combined with cytoreductive surgery may be of considerable value in treatment and prevention of disease dissemination; it should be considered when pleural extension of mucinous tumor is feared or confirmed at the time of cytoreductive surgery.

Key Words

Intraperitoneal chemotherapy Intrapleural chemotherapy Mucinous adenocarcinoma Pseudomyxoma peritonei syndrome 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Sugarbaker PH, Ronnett BM, Archer A, et al. Management of pseudomyxoma peritonei of appendiceal origin.Adv Surg 1997; 30:233–80.Google Scholar
  2. 2.
    Zoetmulder FAN, Sugarbaker PH. Patterns of failure following treatment of pseudomyxoma peritonei of appendiceal origin.Eur J Cancer 1996;32A:1727–33.PubMedCrossRefGoogle Scholar
  3. 3.
    Ronnett BM, Shmookler BM, Sugarbaker PH, Kurman RJ. Pseudomyxoma peritonei: new concepts in diagnosis, origin, nomenclature, and relationship to mucinous borderline (low malignant potential) tumors of the ovary. In: Fechner RE, Rosen PP, eds.Anatomic Pathology. Chicago: American Society of Clinical Pathologists, 1997:197–226.Google Scholar
  4. 4.
    Gough DB, Donohue JH, Schutt JH, et al. Pseudomyxoma peritonei: long-term patient survival with an aggressive regional approach.Ann Surg 1994;219:112–9.PubMedCrossRefGoogle Scholar
  5. 5.
    Sugarbaker PH. Pseudomyxoma peritonei, a cancer whose biology is characterized by a redistribution phenomenon.Ann Surg 1995; 219:109–11.Google Scholar
  6. 6.
    Sugarbaker PH. Observations concerning cancer spread within the peritoneal cavity and concepts supporting an ordered pathophysiology. In: Sugarbaker PH, ed.Peritoneal Carcinomatosis: Principles of Management, Boston: Kluwer, 1996:79–100.Google Scholar
  7. 7.
    Matsuzaki Y, Shibata K, Yoshioka M, et al. Intrapleural perfusion hyperthermo-chemotherapy for malignant pleural dissemination and effusion.Ann Thorac Surg 1995;59:127–31.PubMedCrossRefGoogle Scholar
  8. 8.
    Ichinose Y, Hara N, Ohta M, et al. Hypotonic cisplatin treatment for carcinomatous pleuritis found at thoracotomy in patients with lung cancer.J Thorac Cardiovasc Surg 1993;105:1041–6.PubMedGoogle Scholar
  9. 9.
    Doi O, Kodama K, Higashiyama M, Kuriyama K, Tateishi R. Postoperative chemothermotherapy for locally advanced lung cancer with carcinomatous pleuritis. In: Matsuda T, ed.,Cancer Treatment by Hyperthermia, Radiation and Drugs London: Taylor & Francis, 1993:338–52.Google Scholar
  10. 10.
    Higashiyama M, Doi O, Kodama K, Yokouchi H. Intrathoracic chemotherapy following panpleuropneumectomy for pleural dissemination of invasive thymoma.Chest 1994;105:1884–5.PubMedGoogle Scholar

Copyright information

© The Society of Surgical Oncology, Inc. 2000

Authors and Affiliations

  • Sophie R. Pestieau
    • 1
  • Jesus Esquivel
    • 1
  • Paul H. Sugarbaker
    • 1
  1. 1.Washington Cancer InstituteWashington Hospital CenterWashington, DC

Personalised recommendations