Ultrafiltrate sampling device for continuous monitoring

  • D. Moscone
  • K. Venema
  • J. Korf
Physiological Measurement


A light, portable sampling device for the continuous collection and storage of subcutaneous fluid is described. It consists of a hollow-fibre probe for ultrafiltration, a long tube for sample storage and a vacuum tube as driving force. Introduction of a restriction in the flow path allows a constant pulse-free flow as low as 100 nl min−1. The contents of the storage tube reflect the metabolic events that have happened during the 24 h collection period. The ultrafiltrate fluid collected from the subcutaneous tissue is free from large molecules and can be continuously analysed. An application in combination with a bionsensor for the analysis of glucose is described, but the device also allows monitoring of other subcutaneous constituents such as ions, metabolites, drugs and their metabolites.


Biosensor Glucose Ultrafiltration 24 h monitoring 


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Copyright information

© IFMBE 1996

Authors and Affiliations

  • D. Moscone
    • 1
    • 2
  • K. Venema
    • 1
  • J. Korf
    • 1
  1. 1.Department of Biological PsychiatryUniversity of GroningenGroningenThe Netherlands
  2. 2.Dipartimento di Scienze e Technologie ChimicheUniversita' Tor VergataRomaItaly

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