Archives of Gynecology and Obstetrics

, Volume 259, Issue 2, pp 97–103 | Cite as

Metastasizing placental site trophoblastic tumor: Immunohistochemical and DNA analysis 2 case reports and a review of the literature

  • S. Remadi
  • B. Lifschitz-Mercer
  • H. Ben-Hur
  • R. Dgani
  • B. Czernobilsky
Case Reports


Placental-site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasia. The clinical behaviour of PSTT is usually benign, but sometimes it can be highly malignant with late recurrence and metastasis. We describe two cases of PSTT with pulmonary metastasis in patients aged 35 and 29 years respectively. The mitotic rate was elevated to 9 and 13 mitotic figures per 10 high-power fields respectively. Immunohistochemical staining showed a predominance of human placental lactogen (hPL) positive cells when compared with human chorionic gonadotropin (hCG) reactive cells in one case, and a reverse pattern in the other one. DNA measurement in one case showed an aneuploid tumor with a tetraploid DNA peak. The clinical behaviour of PSTT remains unpredictable, and there are no reliable means of predicting clinical outcome.

Key words

Placental site trophoblastic tumor Metastasis 


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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • S. Remadi
    • 1
  • B. Lifschitz-Mercer
    • 2
  • H. Ben-Hur
    • 3
  • R. Dgani
    • 3
  • B. Czernobilsky
    • 3
  1. 1.Institut de Pathologie CliniqueHôpital Cantonal Universitaire de GenèveGenève 4Switzerland
  2. 2.Institute of PathologySourasky Medical CenterTel AvivIsrael
  3. 3.Dept. of Obstetrics and GynecologyKaplan HospitalRehovotIsrael

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