Chromatographia

, Volume 53, Issue 1–2, pp 11–16 | Cite as

The role of ion pairing in the chromatographic study of propranolol analogues

  • M. M. Britto
  • Q. B. Cass
  • I. C. S. F. Jardim
  • C. A. Montanari
  • H. Y. Aboul-Enein
Originals Column Liquid Chromatography

Summary

The partition coefficients, logP app RPLC, for a series of propranolol analogues have been determined by reversed phase high performance liquid chromatography. The hydrochloride salts and free base logP app RPLC show that charged and uncharged species can partition into the reversed phase. An extrathermodynamic relationship was found for logP app RPLC measured in two different column stationary phases, C8 and PMOS, suggesting that the same set of compounds experience a similar trend in these elution systems. The importance of using phosphate and/or MOPS buffer is due to the fact that the latter can avoid ion-pairing partitioning, but the former does play the same role for PMOS column when the free base is considered.

Key Words

Column liquid chromatography Structure-retention relationships Propranolol analogues 

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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 2001

Authors and Affiliations

  • M. M. Britto
    • 1
  • Q. B. Cass
    • 2
  • I. C. S. F. Jardim
    • 3
  • C. A. Montanari
    • 1
  • H. Y. Aboul-Enein
    • 4
  1. 1.Núcleo de Estudos em Química Medicinal, Departamento de QuímicaUniversidade Federal de Minas GeraisBelo Horizonte MGBrazil
  2. 2.Departamento de QuímicaUniversidade Federal de São CarlosSão CarlosBrazil
  3. 3.Instituto de QuímicaUniversidade Estadual de CampinasCampinasBrazil
  4. 4.Pharmaceutical Analysis Laboratory, Biological and Medical Research Department, MBC-03King Faisal Specialist Hospital & Research CentreRiyadhSaudi Arabia

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