, Volume 46, Issue 1–2, pp 57–62 | Cite as

A highly selective solid phase extraction sorbent for pre-concentration of sameridine made by molecular imprinting

  • L. I. Andersson
  • A. Paprica
  • T. Arvidsson


A novel approach to solid phase extraction, based on the use of a highly selective molecularly imprinted polymer, is presented. The versatility of this type of sorbent for solid phase extraction was demonstrated in a model batch-wise pre-concentration of sameridine prior to gas chromatography. Problems associated with leakage of remaining imprint molecules during the desorption phase could be eliminated by the use of a close structural analogue of sameridine as the imprint species. It was found that a major benefit of the imprinted polymer was its specificity, which lead to distinctly cleaner chromatographic traces and ability to improve sensitivity by extracting sameridine from larger sample volumes.

Key Words

Gas chromatography Solid phase extraction Sample pre-concentration Pre-determined selectivity Synthetic polymer 


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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1997

Authors and Affiliations

  • L. I. Andersson
    • 1
  • A. Paprica
    • 1
  • T. Arvidsson
    • 1
  1. 1.Bioanalytical ChemistryPharmaceutical and Analytical R&DSödertäljeSwerden

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