, Volume 50, Issue 3–4, pp 188–194 | Cite as

Capillary electrophoresis time-of-flight mass spectrometry of an opium powder

  • I. M. Lazar
  • G. Naisbitt
  • M. L. Lee


Intensive work has been invested in recent years to evaluate the performance of capillary electrophoresis (CE) in forensic analysis. Tremendous progress has also been achieved in interfacing CE to sensitive and specific detection systems such as the mass spectrometer (MS). We have recently developed an electrospray time-of-flight mass spectrometer (ESI-TOFMS) for use as a detector for fast and efficient liquid phase separations. In the present paper we investigated ESI-TOFMS for the analysis of an opium powder. Both continuous infusion and CE were studied for direct sample introduction into the TOFMS and mixture separation, respectively. CEMS analysis of the opium was performed in a citrate buffer, using aqueous or mixed aqueous/organic eluents. Low fmol detection was achieved.

Key Words

Capillary electrophoresis Mass spectrometry Time-of-flight Opium Drugs 


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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1999

Authors and Affiliations

  • I. M. Lazar
    • 1
  • G. Naisbitt
    • 2
  • M. L. Lee
    • 1
  1. 1.Department of Chemistry and BiochemistryBrigham Young UniversityProvoUSA
  2. 2.Utah State Crime LaboratorySalt Lake CityUSA

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