Surgery Today

, Volume 28, Issue 7, pp 701–706 | Cite as

Detection of carcinoembryonic antigen mRNA in the mesenteric vein of patients with resectable colorectal cancer

  • Takashi Ueda
  • Junichiro Furui
  • Koh Komuta
  • Junzou Yamaguchi
  • Masayuki Yamamoto
  • Koichi Furukawa
  • Takashi Kanematsu
Original Articles

Abstract

The detection of tumor cells in the drainage venous blood of patients with colorectal cancer was made feasible by demonstrating carcinoembryonic antigen (CEA) mRNA in the mononuclear cell component of the blood, using a nested reverse transcription-polymerase chain reaction. CEA mRNA was detected in the drainage venous blood from 11 (42%) of 26 patients, and the rate of detection increased according to the grade of vessel invasion. CEA mRNA was detected in all patients with synchronous liver metastases, even though there was no significant correlation between the presence of CEA mRNA in the drainage venous blood and the clinicopathological findings. As the presence of CEA mRNA in the drainage venous blood is an indicator of the spread of tumor cells in patients with colorectal cancer, this assay can be used to assess the possible outcome of patients with colorectal cancer, providing one more tool for the physician-oncologist to use in designing appropriate treatments.

Key Words

colorectal cancer CEA mRNA nested RT-PCR liver metastasis mesenteric vein 

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Copyright information

© Springer-Verlag 1998

Authors and Affiliations

  • Takashi Ueda
    • 1
  • Junichiro Furui
    • 1
  • Koh Komuta
    • 1
  • Junzou Yamaguchi
    • 1
  • Masayuki Yamamoto
    • 1
  • Koichi Furukawa
    • 2
  • Takashi Kanematsu
    • 1
  1. 1.Department of Surgery IINagasaki University School of MedicineNagasakiJapan
  2. 2.Department of OncologyNagasaki University School of MedicineNagasakiJapan

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