Thoracic epidural blockade preserves left ventricular early diastolic filling assessed by transesophageal echocardiography
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Abstract
Purpose
The objective of this study was to examine the effect of thoracic epidural anesthesia (TEA) on left ventricular systolic and diastolic function assessed by transesophageal echocardiography under general anesthesia.
Methods
Sixteen patients were allocated to control (n=8) and TEA (n=8) groups. We administered 1% mepivacaine (8.9±1.2 ml) into the thoracic epidural space in the TEA group.
Results
The concomitant decline of the left vertricular systolic functional parameters, such as end-systolic diameter and fractional shortening, was observed, whereas preload, as measured by end-diastolic diameter, and afterload, as measured by end-systolic wall stress, were unchanged. No significant alteration was observed in early peak velocity or deceleration rate. The deceleration time was independent of heart rate and was unchanged.
Conclusion
High TEA reduces fractional shortening without any changes in preload and afterload, indicating impairment of systolic function, but early peak velocity, deceleration rate, and deceleration time, which are the indices of diastolic function, are not changed during high TEA combined with general anesthesia.
Key words
Thoracic epidural anesthesia left ventricular diastolic function Transesophageal echocardiography Transmitral flowPreview
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References
- 1.Labovitz AJ, Lewen MK, Kern M (1987) Evaluation of left ventricular systolic and diastolic dysfunction during transient myocardial ischemia produced by angiography. J Am Coll Cardiol 10:748–755PubMedGoogle Scholar
- 2.Yamada T, Takeda J, Koyama K, Sekiguchi H, Fukushima K, Kawazoe T (1994) Effects of sevoflurane, isoflurane, enflurane, and halothane on left ventricular diastolic performance in dogs. J Cardiothorac Vasc Anesth 6:618–624CrossRefGoogle Scholar
- 3.Houltz E, Caidahl K, Hellstrom A, Gustavsson T, Milocco I, Ricksten S-E (1995) The effects of nitrous oxide on left ventricular systolic and diastolic performance before and after cardiopulmonary bypass: evaluation by computer-assisted two-dimensional and doppler echocardiography in patients undergoing coronary artery surgery. Anesth Analg 81:243–248PubMedCrossRefGoogle Scholar
- 4.Kitahata H, Tanaka K, Kimura H, Saito T (1993) Effects of sevoflurane on left ventricular diastolic function using transesophageal echocardiography. Masui (Jpn J Anethesiol) 42: 358–364PubMedGoogle Scholar
- 5.Samuelsson S, Brodin L-A, Broman M, Owall A, Settergren G (1995) Comparison between transesophageal doppler echocardiography and nuclear cardioangiography for the evaluation of left ventricular filling during coronary artery bypass grafting. Anesth Analg 80:41–46PubMedCrossRefGoogle Scholar
- 6.Kosaka Y (1995) Epidural anesthesia (in Japanese). In: Inada Y, Fujita M, Yamamoto T (eds) Saishin-Masuika Gaku, Kokuseido Co., Tokyo, pp 921–934Google Scholar
- 7.Grossman W, Jones D, McLaurin LP (1975) Wall stress and patterns of hypertrophy in the human left ventricle. J Clin Invest 56:56–64PubMedCrossRefGoogle Scholar
- 8.Wattwil M, Sundberg A, Arvill A, Lennquist C (1985) Circulatory changes during high thoracic epidural anaesthesia—influence of sympathetic block and of systematic effect of the local anaesthetic. Acta Anaesthesiol Scand 29:849–855PubMedGoogle Scholar
- 9.Goertz AW, Seeling W, Heinrich H, Lindner KH, Schimer U (1983) Influence of high thoracic epidural anesthesia on left ventricular contractility assessed using the end-systolic pressure-length relationship. Acta Anaesthesiol Scand 37:38–44CrossRefGoogle Scholar
- 10.Kosai K, Nagata N, Takasaki M, Kondou O (1994) The effect of the spread of cervical epidural analgesia on hemodynamics. J Jpn Soc Clin Anesth 14:33–38Google Scholar
- 11.Ottesen S, Renck H, Jynge P (1978) Thoracic epidural analgesia. An experimental study in sheep of effects on central circulation, regional perfusion and myocardial performance during normoxia, hypoxia and isoproterenol administration. Acta Anesthesiol Scand 69 [Suppl]:1–16Google Scholar
- 12.Mergner GW, Stolte AL, Frame WB, Lim H-J (1994) Combined epidural and general anesthesia induce ischemia distal to a severe coronary artery stenosis in swine. Anesth Analg 78:37–45PubMedCrossRefGoogle Scholar
- 13.Kock M, Blomberg S, Emanuelsson H, Lomsky M, Stromblad S-O, Ricksten S-E (1990) Thoracic epidural anesthesia improves global and regional left ventricular function during stress-induced myocardial ischemia in patients with coronary artery disease. Anesth Analg 71:625–630PubMedCrossRefGoogle Scholar
- 14.Blomberg S, Emanuelsson H, Ricksten S-E (1989) Thoracic epidural anesthesia and central hemodynamics in patients with unstable angina pectoris. Anesth Analg 69:558–562PubMedCrossRefGoogle Scholar
- 15.Suga H, Sagawa K, Shoukas AA (1973) Load independence of the instantaneous pressure-volume ratio of the canine left ventricle and effects of epinephrine and heart rate ratio. Circ Res 32:314–322PubMedGoogle Scholar
- 16.Bonica JJ, Berges PU, Marikawa K (1970) Circulatory effects of peridural block: I Effects of level of analgesia and dose of lidocaine. Anesthesiology 33:619–626PubMedGoogle Scholar
- 17.Thys DM, Dauchot PJ (1993) Advance in cardiovascular physiology. In: Kaplan JA (ed) Cardiac anesthesia, 3rd edn Sauders, Philadelphia, pp 228–232Google Scholar
- 18.Pagel PS, Grossman W, Haering JM, Warltier DC (1993) Left ventricular diastolic function in the normal and diseased heart. Perspectives for the anesthesiologist (first of two parts). Anesthesiology 79:836–854PubMedCrossRefGoogle Scholar
- 19.Nishimura RA, Abel MD, Hatle LK, Tajik AJ (1989) Assessment of diastolic function of the heart: background and current applications of Doppler echocardiography. Part II. Clinical Studies. Mayo Clin Proc 64:180–204Google Scholar
- 20.Harrison MR, Clifton GD, Pennell AT, DeMaria AN, Ceter A (1991) Effect of heart rate on left ventricular diastolic transmitral flow velocity patterns assessed by Doppler echocardiography in normal subjects. Am J Cardiol 67:622–627PubMedCrossRefGoogle Scholar
- 21.Vam Dam I, Fast J, de Boo T, Hopman J, Van Oort A, Heringa A, Alsters J, Van Der Werf T, Daniels O (1988) Normal diastolic filling patterns of left ventricle. Eur Heart J 9:165–171PubMedGoogle Scholar
- 22.Messina AG, Paranicas M, Yao F-S, Illner P, Roman MJ, Saba PS, Devereux RB (1995) The effect of midazolam on left ventricular pump performance and contractility in anesthetized patients with coronary artery disease: effect of preoperative ejection fraction. Anesth Analg 81:793–799PubMedCrossRefGoogle Scholar