Clinical and Experimental Nephrology

, Volume 2, Issue 4, pp 307–312 | Cite as

Mechanisms of progressive glomerulosclerosis and tubulointerstitial fibrosis

  • Richard J. Johnson
  • Christian Hugo
  • Leah Haseley
  • Raimund Pichler
  • James Bassuk
  • Susan Thomas
  • Shinichi Suga
  • William G. Couser
  • Stuart J. Shankland
Frontiers of Nephrology Part 3: Glomerular Scarring and Interstitial Fibrosis


In this paper we provide an overview of the cellular changes that accompany progressive glomerulosclerosis and tubulointerstitial fibrosis. Emphasis is placed on the role of platelet-derived growth factor (PDGF) in the proliferation of the mesangial cell and interstitial fibroblast. PDGF also stimulates the synthesis and expression of a protein called secreted protein acidic and rich in cysteine (SPARC) and of thrombospondin 1 (TSP1). TSP1 may have an important role in the conversion of transforming growth factor (TGF)-β from its latent to active form. In turn, TGF-β appears to have a major role in mediating the extracellular matrix deposition that occurs with progressive glomerular and interstitial scarring.

Key words

glomerulosclerosis interstitial fibrosis PDGF TGF-β SPARC thrombospondin 1 


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Copyright information

© CEN/CLJ 1998

Authors and Affiliations

  • Richard J. Johnson
    • 1
  • Christian Hugo
    • 1
  • Leah Haseley
    • 1
  • Raimund Pichler
    • 1
  • James Bassuk
    • 1
  • Susan Thomas
    • 1
  • Shinichi Suga
    • 1
  • William G. Couser
    • 1
  • Stuart J. Shankland
    • 1
  1. 1.Division of NephrologyUniversity of Washington Medical CenterSeattleUSA

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