Brain Tumor Pathology

, 18:151 | Cite as

Prognostic value of Ki-67 (MIB-1) and p53 in ependymomas

  • Sachio Suzuki
  • Hidehiro Oka
  • Nobuyuki Kawano
  • Satoshi Tanaka
  • Satoshi Utsuki
  • Kiyotaka Fujii
Original Article

Abstract

To determine whether Ki-67 (MIB-1) and p53 have prognostic value in ependymomas, clinicopathologic study was undertaken in 29 patients with this tumor. The clinical course correlated well with the histological grade according to the World Health Organization (WHO) grading system, and it was the worst in patients with anaplastic ependymoma. The percent expression of MIB-1 and p53 correlated with the histological grade of malignancy. With regard to the subtypes of benign ependymoma, the clinical course was the worst in clear-cell ependymoma, which had a significantly higher expression of MIB-1 and p53 than the other subtypes. Tanycytic ependymoma showed the most benign clinical course and the lowest expression of MIB-1 and p53. Although the WHO grading generally tended to correlate with the clinical course of ependymomas, these two subtypes-clear-cell ependymoma and tanycytic ependymoma-exhibited biological properties different from those of other grade II ependymomas.

Key words

Ependymoma Subtype Histologic prognostic factors MIB-1 p53 

References

  1. 1.
    Kleihues P, Cavenee WK (2000) Pathology and genetics tumor of the nervous system. International Agency for Research on Cancer (IARC), Lyon, pp 72–77Google Scholar
  2. 2.
    Schiffer D, Chio A, Giordana MT, et al (1991) Histologic prognostic factors in ependymoma. Child's Nerv Syst 7:177–182CrossRefGoogle Scholar
  3. 3.
    Ernestus RI, Schroder R, Stutzer H, et al (1997) The clinical and prognostic relevance of grading in intracranial ependymomas. Br J Neurosurg 11:421–428PubMedCrossRefGoogle Scholar
  4. 4.
    Min KW, Scheithauer BW (1997) Clear cell ependymoma: a mimic of oligodendroglioma: clinicopathological and ultrastructural considerations. Am J Surg Pathol 21:820–826PubMedCrossRefGoogle Scholar
  5. 5.
    Kleihues P, Burger PC (1993) Histological typing of tumors of the central nervous system. Springer-Verlag, Berlin, pp 17–18Google Scholar
  6. 6.
    Kawano N, Yada K, Yagishita S (1989) Clear cell ependymoma: a histologic variant with diagnostic implications. Pathol Anat histopathol 415:467–472CrossRefGoogle Scholar
  7. 7.
    Kawano N, Yagishita S, Komatsu K, et al (1999) Cerebellar clear cell ependymoma mimicking hemangioblastoma; its clinical and pathological features. Surg Neurol 51:281–288PubMedCrossRefGoogle Scholar
  8. 8.
    Kawano N, Yada K, Suwa T, et al (1989) Oligodendroglioma-like cell in ependymoma. Acta Neuropathol (Berl) 62:141–144CrossRefGoogle Scholar
  9. 9.
    Takakusaki H, Akimoto J, Ohiwa Y, et al (1999) One case of clear cell ependymoma. Neurooncology 9:93–95Google Scholar
  10. 10.
    Kakita A, Takahashi H, Fusejima T, et al (1995) Clear cell variants of intracranial tumors: meningioma and ependymoma. Brain Tumor Pathol 12:111–116Google Scholar
  11. 11.
    Friede RL, Pollak A (1978) The cytogenetic basis for classifying ependymomas. J Neuropathol Exp Neurol 37:103–118PubMedGoogle Scholar
  12. 12.
    Prayson RA (1999) Clinicopathological study of 61 patients with ependymoma including MIB-1 immunohistochemistry. Ann Diagn Pathol 3:11–18PubMedCrossRefGoogle Scholar
  13. 13.
    Langofrd LA, Barre GM (1997) Tanycytic ependymoma. Ultrastruct Pathol 21:135–142Google Scholar
  14. 14.
    Hayashi S, Kameyama S, Fukuda M, et al (2000) Ganglioma with a tanycytic ependymoma as the glial component. Acta Neuropathol (Berl) 99:310–316CrossRefGoogle Scholar
  15. 15.
    Daneyemez M, Can C, Izci Y, et al (1999) The tanycytic ependymoma of the lateral ventricle: case report. Minim Invas Neurosurg 42:20–23Google Scholar
  16. 16.
    Kawano N, Yagishita S, Oka H, et al (2004) Spinal tanycytic ependymomas: case reports. Acta Neuropathol (Berl) (in press)Google Scholar
  17. 17.
    Ritter AM, Hess KR, McLendon RE, et al (1998) Ependymoma: MIB-1 proliferation index and survival. J Neurooncol 40:51–57PubMedCrossRefGoogle Scholar
  18. 18.
    Schroder R, Ploner C, Ernestus RI (1993) The growth potential of ependymomas with varying grades of malignancy measured by the Ki-67 labelling and mitotic index. Neurosurg Rev 16:145–150PubMedCrossRefGoogle Scholar
  19. 19.
    Karamitopoulou E, Perentes E, Diamantis I, et al (1994) Ki-67 immunoreactivity in human central nervous system tumors: a study with MIB-1 monoclonal antibody on archival material. Acta Neuropathol (Berl) 87:47–54CrossRefGoogle Scholar
  20. 20.
    Louis DN, Edgerton S, Thor AD, et al (1991) Proliferation cell nuclear antigen and Ki-67 immunohistochemistry in brain tumors: a comparative study. Acta Neuropathol (Berl) 81:675–679CrossRefGoogle Scholar
  21. 21.
    Schroder R, Ploner C, Ernestus RI (1993) The growth potential of ependymomas with varying grades of malignancy measured by the Ki-67 labelling and mitotic index. Neurosurg Rev 16:145–150PubMedCrossRefGoogle Scholar
  22. 22.
    Sidransky D, Mikkelsen T, Schwechheimer K, et al (1992) Clonal expansion of p53 mutant cells is associated with brain tumor progression. Nature 355:846–847PubMedCrossRefGoogle Scholar
  23. 23.
    Tominaga T, Katayama T, Kumabe T, et al (1995) Anaplastic ependymoma: clinical features and tumor suppressor gene p53 analysis. Acta Neurochir (Wien) 135:163–170CrossRefGoogle Scholar
  24. 24.
    Fink KL, Rushing EJ, Scholf SC Jr, et al (1996) Infrequency of p53 gene mutations in ependymomas. J Neurooncol 27:111–115PubMedCrossRefGoogle Scholar
  25. 25.
    Metzger AK, Scheffield VC, Duyk G, et al (1991) Identification of a germ-line mutation in the p53 gene in a patient with an intracranial ependymoma. Proc Natl Acad Sci USA 88:7825–7829PubMedCrossRefGoogle Scholar
  26. 26.
    Nozaki M, Tada M, Matsumoto R, et al (1998) Rare occurrence of inactivating p53 gene mutation in primary non-astrocytic tumors of the central nervous system: reappraisal by yeast functional assay. Acta Neuropathol (Berl) 95:291–296CrossRefGoogle Scholar

Copyright information

© The Japan Society of Brain Tumor Pathology 2001

Authors and Affiliations

  • Sachio Suzuki
    • 1
  • Hidehiro Oka
    • 1
  • Nobuyuki Kawano
    • 2
  • Satoshi Tanaka
    • 1
  • Satoshi Utsuki
    • 1
  • Kiyotaka Fujii
    • 1
  1. 1.Department of NeurosurgeryKitasato University School of MedicineSagamihara, KanagawaJapan
  2. 2.Isobe ClinicSagamihara, KanagawaJapan

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