Brain Tumor Pathology

, Volume 19, Issue 2, pp 93–96

A melanotic desmoplastic medulloblastoma: Report of a rare case and review of the literature

  • M. C. Sharma
  • M. Agarwal
  • A. Suri
  • S. Gaikwad
  • P. Mukhopadhyay
  • C. Sarkar
Case Report


A 28-year-old man had a desmoplastic medullo-blastoma in the vermis and left cerebellum. This tumor was composed of nodular, reticulin-free zones (pale islands) surrounded by densely packed, highly proliferative cells that produced a dense intercellular reticulin network. Some of the cells were heavily pigmented, and this pigment proved to be melanin. Adult age, desmoplastic nature, and melanin pigmentation are some of the rare features of this tumor that need documentation. Further, this pigment was in the primitive cells, unlike in the published cases, in which it was present in the tubular or tubulopapillary component. To the best of our knowledge, this is the first published case of desmoplastic pigmented medulloblastoma, and the patient is the oldest reported to have this tumor.

Key words

Melanotic medulloblastoma Pigmented Melanin Desmoplastic Adult PNET Central nervous system Tumor 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Fowler M, Simpson DA (1962) A malignant melanin forming tumour of the cerebellum. J Pathol Bact 84:307–311CrossRefGoogle Scholar
  2. 2.
    Rubinstein LJ, Northfield DWC (1964) Medulloblastoma and so-called “arachnoidal cerebellar sarcoma.” A critical re-examination of a nosological problem. Brain 87:379–414PubMedGoogle Scholar
  3. 3.
    Best PV (1973) A medulloblastoma-like-tumour with melanin formation. J Pathol 110:109–111PubMedCrossRefGoogle Scholar
  4. 4.
    Sung JH, Mastri AR, Segal EL (1973) Melanotic medulloblastoma of the cerebellum. Report of a case. J Neuropathol Exp Neurol 32:437–445PubMedGoogle Scholar
  5. 5.
    Hahn JF, Sperber EE, Netsky MG (1976) Melanotic neuroectodermal tumors of the brain and skull. J Neuropathol Exp Neurol 35:508–519PubMedGoogle Scholar
  6. 6.
    Boesel CP, Suhan JP, Sayers MP (1978) Melanotic medulloblastoma. Report of a case with ultrastructural findings. J Neuropathol Exp Neurol 37:531–543PubMedGoogle Scholar
  7. 7.
    Jimenez CL, Carpenter BF, Robb IA (1987) Melanotic cerebellar tumour. Ultrastruct Pathol 11:751–759PubMedGoogle Scholar
  8. 8.
    Dolman CL (1988) Melanotic medulloblastoma: a case report with immunohistochemical and ultrastructural examination. Acta Neuropathol 76:528–531PubMedCrossRefGoogle Scholar
  9. 9.
    Garcia-Bragado F, Cabello A, Guarch R, et al (1990) Melanotic medulloblastoma. Ultrastructural and histochemical study of a case. Arch Neurbiol (Madr) 53:8–12Google Scholar
  10. 10.
    Baylac F, Martinoli A, Marie B, et al (1997) An exceptional variety of medulloblastoma: melanotic medulloblastoma. Ann Pathol 17:403–405PubMedGoogle Scholar
  11. 11.
    Krompecher E (1918) Zur Histogenese und Morphologie der Adamantinome und sonstiger kiefergesch Wuelste. Beitr Path Anat 64:169–197Google Scholar
  12. 12.
    Sharma MC, Mahapatra AK, Gaikwad S (1996) Pigmented neuro-ectodermal tumour of infancy: immunohistogenetic consideration. JAPI 44:278–280PubMedGoogle Scholar
  13. 13.
    Stowens D (1996) Pediatric pathology, 2nd edn. Williams and Wilkins, BaltimoreGoogle Scholar
  14. 14.
    Stowens D (1957) A pigmented tumour of infancy: the melanotic prognoma. J Path Bact 73:43–51CrossRefGoogle Scholar
  15. 15.
    Sharma MC, Arora R, Khanna N, et al (2001) Pigmented pleomorphic xanthoastrocytoma: report of a rare case with review of literature. Arch Path Lab Med 125:808–811PubMedGoogle Scholar
  16. 16.
    Borello ED, Gorlin RJ (1966) Melanotic neuroectodermal tumour of infancy—a neoplasm of neural crest origin: report of a case associated with high urinary excretion of vanillmandelic acid. Cancer 19:196–206PubMedCrossRefGoogle Scholar
  17. 17.
    Cutler LS, Chaudhry AP, Topazian R (1981) Melanotic neuroectodermal tumour of infancy. An ultrastructural study, literature review and re-evaluation. Cancer 48:157–170CrossRefGoogle Scholar
  18. 18.
    Kalimo H, Paljarvi L, Ekfors T, et al (1987) Pigmented primitive neuroectodermal tumor with multi-potential differentiation in cerebellum (pigmented medullomyoblastoma): a case with light and electron microscopy, and immunohistochemical analysis. Pediatr Neurosci 13:188–195PubMedCrossRefGoogle Scholar
  19. 19.
    Eusebi V, Damiani S, Pasquinelli, G, et al (2000) Small cell neuroendocrine carcinoma with skeletal muscle differentiation. Report of three cases. Am J Surg Pathol 24:223–230PubMedCrossRefGoogle Scholar

Copyright information

© The Japan Society of Brain Tumor Pathology 2002

Authors and Affiliations

  • M. C. Sharma
    • 1
  • M. Agarwal
    • 1
  • A. Suri
    • 2
  • S. Gaikwad
    • 3
  • P. Mukhopadhyay
    • 4
  • C. Sarkar
    • 1
  1. 1.Department of PathologyAll India Institute of Medical SciencesNew DelhiIndia
  2. 2.Department of NeurosurgeryAll India Institute of Medical SciencesNew DelhiIndia
  3. 3.Department of NeuroradiologyAll India Institute of Medical SciencesNew DelhiIndia
  4. 4.Department of Radiation OncologyAll India Institute of Medical SciencesNew DelhiIndia

Personalised recommendations