Brain Tumor Pathology

, Volume 18, Issue 1, pp 1–5 | Cite as

Different distribution of c-myc and MIB-1 positive cells in malignant meningiomas with reference to TGFs, PDGF, and PgR expression

  • Goro Nagashima
  • Jun-ichirou Asai
  • Ryuta Suzuki
  • Tsukasa Fujimoto
Original Article

Abstract

We investigated the expression of transforming growth factors (TGFs), platelet-derived growth factor (PDGF), progesterone receptor (PgR), and c-myc in 20 cases of meningioma of various grades: 17 benign, 2 atypical, and 1 anaplastic. All cases of atypical and anaplastic meningioma were positive for c-myc, whereas all 17 benign meningiomas were negative for c-myc immunostaining. Expression of TGF-α, TGF-β, and PDGF-BB proteins was seen in more than 80% of the meningioma cases and was not restricted to their histological grade of meningioma. PgR was expressed mainly in benign meningiomas. Moreover, the cells expressing c-myc protein were not usually stained by MIB-1. These results indicate that c-myc does not directly work on the proliferation of meningioma cells, and even in homogeneous meningioma cells, there may be many functional variations that lead the meningioma cells to their growth.

Key words

Meningioma Malignant c-myc Ki-67 

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References

  1. 1.
    Jääskeläinen J, Haltia M, Servo A (1986) Atypical and anaplastic meningiomas: radiology, surgery, radiotherapy, and outcome. Surg Neurol 25:233–242PubMedCrossRefGoogle Scholar
  2. 2.
    Mahmood A, Caccamo DV, Tomecek FJ, et al (1993) Atypical and malignant meningiomas: a clinicopathological review. Neurosurgery 33:955–963PubMedGoogle Scholar
  3. 3.
    Nagashima G, Aoyagi M, Wakimoto H, et al (1995) Immunohistochemical detection of progesterone receptors and the correlation with Ki-67 labelling indices in paraffin-embedded sections of meningiomas. Neurosurgery 37:478–483PubMedGoogle Scholar
  4. 4.
    Nagashima G, Aoyagi M, Yamamoto M, et al (1999) p53 overexpression and proliferative potential in malignant meningiomas. Acta Neurochir (Wien) 141:53–61CrossRefGoogle Scholar
  5. 5.
    Kleihues P, Burger PC, Scheithauer BW (1993) Histological typing of tumours of the central nervous system. Springer-Verlag, New YorkGoogle Scholar
  6. 6.
    Shin RW, Iwaki T, Kitamoto T, et al (1991) Methods in laboratory investigation, hydrated autoclave pretreatment enhances tau immunoreactivity in formalin-fixed normal and Alzheimer's disease brain tissues. Lab Invest 64:693–702PubMedGoogle Scholar
  7. 7.
    Wakimoto H, Aoyagi M, Nakayama T, et al (1996) Prognostic significance of Ki-67 labeling indices obtained using MIB-1 monoclonal antibody in patients with supratentorial astrocytomas. Cancer 77:373–380PubMedCrossRefGoogle Scholar
  8. 8.
    Alitalo K, Koskinen P, Makela TP, et al (1987) myc oncogenes: activation and amplification. Biochem Biophys Acta 907:1–32PubMedGoogle Scholar
  9. 9.
    Luscher B, Eisenman RN (1990) New light on Myc and Myb. Part I. Myc. Genes Dev 4:2025–2035Google Scholar
  10. 10.
    Meichle A, Philipp A, Eilers M (1992) The functions of Myc proteins. Biochem Biophys Acta 1114:129–146PubMedGoogle Scholar
  11. 11.
    Detta A, Kenny BG, Smith C, et al (1993) Correlation of protooncogene expression and proliferation in meningiomas. Neurosurgery 33:1065–1074PubMedGoogle Scholar
  12. 12.
    Kazumoto K, Tamura M, Hoshino H, et al (1990) Enhanced expression of the sis and c-myc oncogenes in human meningiomas. J Neurosurg 72:786–791PubMedCrossRefGoogle Scholar
  13. 13.
    Tanaka K, Sato C, Maeda Y, et al (1989) Establishment of a human malignant meningioma cell line with amplified c-myc oncogene. Cancer 64:2243–2249PubMedCrossRefGoogle Scholar
  14. 14.
    Johnson MD, Federspiel CF, Gold LI, et al (1992) Transforming growth factor-beta and transforming growth factor beta-receptor expression in meningioma cells. Am J Pathol 141:633–642PubMedGoogle Scholar
  15. 15.
    Nitta T, Sato K, Okumura K (1991) Transforming growth factor (TGF)-beta like activity of intracranial meningioma and its effect on cell growth. J Neurol Sci 101:19–23PubMedCrossRefGoogle Scholar
  16. 16.
    Hsu DW, Efird JT, Hedley-Whyte ET (1998) MIB-1 (Ki-67) index and transforming growth factor-alpha (TGF alpha) immunoreactivity are significant prognostic predictors for meningiomas. Neuropathol Appl Neurobiol 24:441–452PubMedCrossRefGoogle Scholar
  17. 17.
    Black PM, Carroll R, Glowacka D, et al (1994) Platelet-derived growth factor expression and stimulation In human meningiomas. J Neurosurg 81:388–393PubMedCrossRefGoogle Scholar
  18. 18.
    Asai J, Suzuki R, Fujimoto T, et al (1999) Fluorescence automatic cell sorter and immunohistochemical investigation of CD68-positive cells in meningioma. Clin Neurol Neurosurg 101:229–234PubMedCrossRefGoogle Scholar
  19. 19.
    Maxwell M, Galanopoulos T, Hedley-Whyte ET, et al (1990) Human meningiomas co-express platelet-derived growth factor (PDGF) and PDGF-receptor genes and their protein products. Int J Cancer 46:16–21PubMedGoogle Scholar
  20. 20.
    Bissonnette RP, Echeverri F, Mahboubi A, et al (1992) Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature 359:552–554PubMedCrossRefGoogle Scholar
  21. 21.
    Fanidi A, Harrington EA, Evan GI (1992) Cooperative interaction between c-myc and bcl-2 proto-oncogenes. Nature, 359:554–556PubMedCrossRefGoogle Scholar
  22. 22.
    Shi Y, Glynn JM, Guilbert LJ, et al (1992) Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas. Science 257:212–214PubMedGoogle Scholar
  23. 23.
    Evan GI, Hancock D, Bennet M, et al (1994) c-myc, In: Mihich E, Schimke RT (eds) Apoptosis. Plenum Press, New York, pp 63–84Google Scholar
  24. 24.
    Strasser A, Harris AW, Bath ML, et al (1990) Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature 348:331–333PubMedCrossRefGoogle Scholar
  25. 25.
    Spencer CA, Groudine M (1991) Control of c-myc regulation in normal and neoplastic cell. Adv Cancer Res 56:1–48PubMedCrossRefGoogle Scholar
  26. 26.
    Perry A, Jenkins RB, Dahl RJ, et al (1996) Cytogenetic analysis of aggressive meningiomas: possible diagnostic and prognostic implications. Cancer 77:2567–2573PubMedCrossRefGoogle Scholar

Copyright information

© The Japan Society of Brain Tumor Pathology 2001

Authors and Affiliations

  • Goro Nagashima
    • 1
  • Jun-ichirou Asai
    • 1
  • Ryuta Suzuki
    • 1
  • Tsukasa Fujimoto
    • 1
  1. 1.Department of NeurosurgeryShowa University, Fujigaoka HospitalKanagawaJapan

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