Brain Tumor Pathology

, Volume 16, Issue 1, pp 17–21 | Cite as

Anomalous p27kip1 expression in a subset of malignant gliomas

Original Article
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Abstract

p27Kip1 (p27) expression was immunohistochemically investigated in 28 astrocytic tumors, and compared with the cell proliferation index (MIB-1 staining index). Normal rat brains and surgical specimens from human nonneoplastic brain lesions were used as controls. In the rat brains, the astrocytes were exclusively p27-positive. The reactive astrocytes in various disease processes sometimes lacked p27 expression. The distribution of p27-positive cells was uniform in low-grade astrocytomas and heterogeneous in high-grade tumors. Double staining of p27 and MIB-1 showed a reciprocal pattern in most cases. The frequency of p27 expression was inversely correlated with MIB-1 staining index and tumor grade. However, several malignant gliomas showed high p27 expression in spite of high MIB-1 staining indices. In such cases, MIB-1-positive cells were occasionally p27-positive. In this paper we discuss the etiology of the anomalous p27 expression in a subset of malignant gliomas.

Key words

Astrocytoma Glioblastoma p27kip1 MIB-1 
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Copyright information

© The Japan Society of Brain Tumor Pathology 1999

Authors and Affiliations

  • Satoshi Nakasu
    • 1
  • Masayuki Nakajima
    • 1
  • Jyoji Handa
    • 1
  1. 1.Department of NeurosurgeryShiga University of Medical ScienceShigaJapan

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