Brain Tumor Pathology

, Volume 14, Issue 1, pp 27–33

Expression and role of cadherins in astrocytic tumors

  • Kenichiroh Asano
  • Osami Kubo
  • Yasuhiko Tajika
  • Ming-Chao Huang
  • Kintomo Takakura
  • Kunihiko Ebina
  • Shigeharu Suzuki
Original Article

Abstract

Cadherins are Ca2+-dependent cell adhesion molecules that play an important role in tissue formation and morphogenesis in multicellular organisms. In recent years, there have been reports of cadherin involvement in tumor invasion and metastasis. Twenty-two surgical specimens and some cultured cells were studied by immunohistochemical staining. No significant difference was observed in the patients with anaplastic astrocytoma, whereas decreased expression of N-cadherin was detected at the time of recurrence in those with glioblastoma. In these groups, cerebrospinal fluid dissemination was found, and contralateral cerebral metastases and extracranial metastases were observed. We conclude that decreased N-cadherin expression at the immunohistochemically demonstrated time of recurrence correlates with tumor invasion and dissemination of cerebrospinal fluid.

Key words

N-cadherin E-cadherin Glioblastoma Anaplastic astrocytoma Dissemination Invasion 

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Copyright information

© The Japan Society of Brain Tumor Pathology 1997

Authors and Affiliations

  • Kenichiroh Asano
    • 1
    • 2
  • Osami Kubo
    • 2
  • Yasuhiko Tajika
    • 2
  • Ming-Chao Huang
    • 2
  • Kintomo Takakura
    • 2
  • Kunihiko Ebina
    • 1
  • Shigeharu Suzuki
    • 1
  1. 1.Department of NeurosurgeryHirosaki University, School of MedicineAomoriJapan
  2. 2.Department of NeurosurgeryNeurological Institute, Tokyo Women's Medical CollegeJapan

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