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The bulletin of mathematical biophysics

, Volume 27, Supplement 1, pp 21–37 | Cite as

Model studies of blood-glucose regulation

  • Eugene Ackerman
  • Laël C. Gatewood
  • John W. Rosevear
  • George D. Molnar
Article

Abstract

A simplified, linearized model of the system regulating blood-glucose concentrations is reviewed. This model, which predicts a damped sine wave response to an oral glucose load, lumps the large number of kinetic parameters into a much smaller number which can, at least in part, characterize the human glucose regulatory system. The predictions based on the model are compared with measurements of blood-glucose and blood-insulin concentrations during the oral glucose-tolerance test. Various other conditions are simulated and their implications are discussed in terms of the mathematical model used.

Keywords

Growth Hormone Glucose Load Glucose Curve Mental Construct Abnormal Glucose Regulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature

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Copyright information

© N. Rashevsky 1965

Authors and Affiliations

  • Eugene Ackerman
    • 1
  • Laël C. Gatewood
    • 1
  • John W. Rosevear
    • 1
  • George D. Molnar
    • 1
  1. 1.Mayo Foundation, Mayo Clinic, and Mayo Graduate School of MedicineRochester

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