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The Japanese journal of surgery

, Volume 15, Issue 6, pp 427–437 | Cite as

Co-carcinogenic effects of several Korean foods on gastric cancer induced by N-methyl-N′-nitro-N-nitrosoguanidine in rats

  • Jin-Pok Kim
  • Jae-Gahb Park
  • Myung-Duck Lee
  • Man-Dong Han
  • Soon-Tae Park
  • Bong-Hwa Lee
  • Sung-Eun Jung
Review Articles

Abstract

In study I, 48 ACI and Fisher inbred rats were given MNNG 100 μg/ml, with or without 1 per cent or 3 per cent red pepper diet; in study II, 164 Sprague-Dawley rats given MNNG 100 μg/ml, with or without 5 per cent or 10 per cent NaCl; in study III, 181 Wistar rats given MNNG 83 μg/ml with or without maejoo 10 gm per cent/diet; in study IV, 78 Wistar rats given MNNG 83 μg/ml with or without ginseng extract 150 μg/ml; in study V, 120 Wistar rats given MNNG 83 μg/ml with or without retinyl palmitate 150,000 IU/kg. Except for study II (28 weeks), all rats were fed the diets for 37 weeks and were examined at 38 weeks or 40 weeks. In study I, tumor incidence in rats fed a red pepper diet and MNNG solution were 57 per cent (ACI rats, 1 per cent red pepper) and 63 per cent (Fisher rats, 1 per cent or 3 per cent red pepper) which were higher than control group (44 per cent, 43 per cent); in study II, gastric cancer, 61.9 per cent (10 per cent NaCl-MNNG), 27.3 per cent (control); in study III, gastric cancer, 14.8 per cent (maejoo-MNNG), 24 per cent (control); in study IV, malignant tumor of gastroduodenum, 3.4 per cent (ginseng-MNNG), 32.1 per cent (control); in study V, forestomach papilloma, 10.7 per cent (retinoid-MNNG), 29.4 per cent (control), and cancer in duodenum and small intestine, 50.0 per cent (retinoid-MNNG), 17.6 per cent (control). Thus, gastric carcinogenesis was enhanced by red pepper and a high salt diet, was inhibited by a maejoo and ginseng diet and was not effected by vitamin A.

Keywords

Gastric Cancer Aflatoxin Angiosarcoma Panax Ginseng Gastric Carcinogenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Japan Surgical Society 1985

Authors and Affiliations

  • Jin-Pok Kim
    • 1
  • Jae-Gahb Park
    • 1
  • Myung-Duck Lee
    • 1
  • Man-Dong Han
    • 1
  • Soon-Tae Park
    • 1
  • Bong-Hwa Lee
    • 1
  • Sung-Eun Jung
    • 1
  1. 1.Department of SurgerySeoul National University, College of MedicineSeoulKorea

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