The Japanese journal of surgery

, Volume 15, Issue 6, pp 427–437 | Cite as

Co-carcinogenic effects of several Korean foods on gastric cancer induced by N-methyl-N′-nitro-N-nitrosoguanidine in rats

  • Jin-Pok Kim
  • Jae-Gahb Park
  • Myung-Duck Lee
  • Man-Dong Han
  • Soon-Tae Park
  • Bong-Hwa Lee
  • Sung-Eun Jung
Review Articles


In study I, 48 ACI and Fisher inbred rats were given MNNG 100 μg/ml, with or without 1 per cent or 3 per cent red pepper diet; in study II, 164 Sprague-Dawley rats given MNNG 100 μg/ml, with or without 5 per cent or 10 per cent NaCl; in study III, 181 Wistar rats given MNNG 83 μg/ml with or without maejoo 10 gm per cent/diet; in study IV, 78 Wistar rats given MNNG 83 μg/ml with or without ginseng extract 150 μg/ml; in study V, 120 Wistar rats given MNNG 83 μg/ml with or without retinyl palmitate 150,000 IU/kg. Except for study II (28 weeks), all rats were fed the diets for 37 weeks and were examined at 38 weeks or 40 weeks. In study I, tumor incidence in rats fed a red pepper diet and MNNG solution were 57 per cent (ACI rats, 1 per cent red pepper) and 63 per cent (Fisher rats, 1 per cent or 3 per cent red pepper) which were higher than control group (44 per cent, 43 per cent); in study II, gastric cancer, 61.9 per cent (10 per cent NaCl-MNNG), 27.3 per cent (control); in study III, gastric cancer, 14.8 per cent (maejoo-MNNG), 24 per cent (control); in study IV, malignant tumor of gastroduodenum, 3.4 per cent (ginseng-MNNG), 32.1 per cent (control); in study V, forestomach papilloma, 10.7 per cent (retinoid-MNNG), 29.4 per cent (control), and cancer in duodenum and small intestine, 50.0 per cent (retinoid-MNNG), 17.6 per cent (control). Thus, gastric carcinogenesis was enhanced by red pepper and a high salt diet, was inhibited by a maejoo and ginseng diet and was not effected by vitamin A.


Gastric Cancer Aflatoxin Angiosarcoma Panax Ginseng Gastric Carcinogenesis 
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  1. 1.
    Sugimura T, Fujimura S. Tumour production in glandular stomach of rat by N-methyl-N′-nitro-N-nitrosoguanidine. Nature 1967; 216: 943–944.PubMedCrossRefGoogle Scholar
  2. 2.
    Sugimura T, Fujimura S, Baba T. Tumor production in the glandular stomach and alimentary tract of the rat by N-methyl-N′-nitro-N-nitrosoguanidine. Cancer Res 1970; 30: 455–465.PubMedGoogle Scholar
  3. 3.
    Sugimura T, Fujimura S, Kogure K, Baba T, Saito T, Nagao M, Hosoi H, Shimosato Y, Yokoshima T. Production of adenocarcinomas in glandular stomach of experimental animals by N-methyl-N′-nitro-N-nitrosoguanidine. Gann Monograph 1969; 8: 157–196.Google Scholar
  4. 4.
    Lee SO. Studies on the influence of diets and lipotropic substances upon the various organs and metabolic changes in rabbits on long term feeding with red pepper. Korean J Int Med 1963; 6: 471.Google Scholar
  5. 5.
    Hirayama T. The epidemiology of cancer of the stomach in Japan; with special reference to the role of diet. Gann Monograph 1968; 3: 15–21.Google Scholar
  6. 6.
    Hirayama T. Epidemiology of stomach cancer. Gann Monograph 1971; 11: 3–19.Google Scholar
  7. 7.
    Sato T, Fukuyama T, Suzuki T, Takayanagi J, Murakami T, Shiotsuki N, Tanaka R, Tsuji R. Studies of the causation of gastric cancer (2. The relation between gastric cancer mortality rate and salted food intake in several places in Japan). Bull Inst Public Health 1959; 8: 187–198.Google Scholar
  8. 8.
    Takahashi M, Kokubo T, Furukawa F, Kurokawa Y, Tatematsu M, Hayashi Y. Effect of high salt diet on rat gastric carcinogenesis induced by N-methyl-N′-nitro-N-nitrosoguanidine. Carcinogenesis 1982; 3: 1419–1422.Google Scholar
  9. 9.
    Shirai T, Imaida K, Fukushima S, Hasegawa R, Tatematsu M, Ito N. Effects of NaCl, Tween 60 and a low dose of N-ethyl-N′-nitro-N-nitrosoguanidine on gastric carcinogenesis of rat given a single dose of N-methyl-N′-nitro-N-nitrosoguanidine. Carcinogenesis 1982; 3: 1419–1422.PubMedGoogle Scholar
  10. 10.
    Correa P, Haenszel W, Cuello C, Tannenbaum S, Archer M. A model for gastric cancer epidemiology. Lancet 1975; 2: 58–59.PubMedCrossRefGoogle Scholar
  11. 11.
    Kim YH, Hwangbo JS, Lee SR. Detection of aflatoxins in some Korean foodstuffs. Korean J Food Science Technol 1977; 9: 73–80.Google Scholar
  12. 12.
    Lee KY, Lee SR. Producibility of aflatoxins by Aspergillus flavus group isolated from deteriorated rice in Korea. Korean J Food Sci Technol 1974; 6: 169–176.Google Scholar
  13. 13.
    Chung Y, Kwon SP. Study on aflatoxins in Korean fermented foodstuffs. J Pre Med (Korea) 1969; 2: 1–4.Google Scholar
  14. 14.
    Crane PS, Rhee SU, Seel DJ. Experience with 1,079 cases of cancer of the stomach seen in Korea from 1962 to 1968. Am J Surg 1970; 120: 747–751.PubMedGoogle Scholar
  15. 15.
    Takahashi M, Shirai T, Fukushima S, Hananouchi M, Hirose M, Ito N. Effect of fundic ulcers induced by iodoacetamide on development of gastric tumors in rats treated with N-methyl-N′-nitro-N-nitrosoguanidine. Gann 1976; 67: 47–54.PubMedGoogle Scholar
  16. 16.
    Cha SM, Hwang WI. Federation Proceedings 1975; 34: 3315.Google Scholar
  17. 17.
    Hwang WI, Cha SM. A cytotoxic activity of extract of panax ginseng root against some cancer cellsin vitro andin vivo. Proc 2nd Int Ginseng Gymp 1978; Korea: 43–49.Google Scholar
  18. 18.
    Lee KD, Huemer RP. Antitumoral activity of panax ginseng extracts. Jpn J Pharm 1971; 21: 299–302.Google Scholar
  19. 19.
    Yuan GC, Chang RS. Testing of compounds for capacity to prolong postmitotic life-span of cultured human amnion cells. Effect of steroids and panax ginseng. J Gerontol 1969; 24: 82–85.PubMedGoogle Scholar
  20. 20.
    Woo LK, Nakamura Y, Donati L. Effect of Korean Gomseng o the growth rate of cells. Drug Research, SNU 1965; IV: 1–9.Google Scholar
  21. 21.
    Grubbs CJ, Moon RC, Sporn MB, Newton DL. Inhibition of mammary cancer by retinyl methyl ether. Cancer Res 1977; 37: 599–602.Google Scholar
  22. 22.
    Kawamura H, Hashimoto Y. Vitamin A receptor in cancers andin vitro-transformed epithelial cells of the rat urinary bladder: Its implication in the preventive effect of vitamin A onin vitro Keratinization. Gann 1980; 71: 507–513.PubMedGoogle Scholar
  23. 23.
    Sporn MB. Retinoids and carcinogenesis. Nutr Rev 1977; 35: 65–69.PubMedCrossRefGoogle Scholar
  24. 24.
    Moon RC, Grubbs CJ, Sporn MB, Goodman DG. Retinyl acetate inhibits mammary carcinogenesis induced by N-methyl-N-nitrosourea. Nature 1977; 267: 620–621.PubMedCrossRefGoogle Scholar
  25. 25.
    Hill DL, Shih TW. Vitamin A compounds and analogs as inhibitors of mixed-function oxidases that metabolize carcinogenic polycyclic hydrocarbons and other compounds. Cancer Res 1974; 34: 564–570.PubMedGoogle Scholar
  26. 26.
    Bornstein WA, Lamden MP, Chuang AHL, Gross RL, Newberne PM, Bresnick E. Inability of vitamin A deficiency to alter benzo(a)pyrene metabolism in Syrian hamsters. Cancer Res 1978; 38: 1497–1501.PubMedGoogle Scholar
  27. 27.
    Chytil F, Ong DE. Mediation of retinoic acid-induced growth and anti-tumour activity. Nature 1976; 260: 49–51.PubMedCrossRefGoogle Scholar
  28. 28.
    Smith FR, Goodman DS. Vitamin A transport in human vitamin A toxicity. New Engl J Med 1976; 294: 805–808.PubMedCrossRefGoogle Scholar
  29. 29.
    Weiss L, Holyoke ED. Some effects of hypervitaminosis A on metastasis of spontaneous breast cancer in mice. J Nat Cancer Inst 1969; 43: 1045–1054.PubMedGoogle Scholar

Copyright information

© The Japan Surgical Society 1985

Authors and Affiliations

  • Jin-Pok Kim
    • 1
  • Jae-Gahb Park
    • 1
  • Myung-Duck Lee
    • 1
  • Man-Dong Han
    • 1
  • Soon-Tae Park
    • 1
  • Bong-Hwa Lee
    • 1
  • Sung-Eun Jung
    • 1
  1. 1.Department of SurgerySeoul National University, College of MedicineSeoulKorea

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