The Japanese journal of surgery

, Volume 13, Issue 2, pp 112–116 | Cite as

Late results of postoperative long-term cancer chemotherapy for the gastric cancer patients subjected to curative resection

  • Tadashi Kano
  • Ryunosuke Kumashiro
  • Hidetaka Masuda
  • Ryuichiro Tamada
  • Kiyoshi Inokuchi
Original Communications

Abstract

Postoperative long-term cancer chemotherapy (PLCC) with a combination of Mitomycin-C (MMC), FT-207 and PSK (an immunostimulant) was prescribed for gastric cancer patients subjected to curative resection. The 5 year survival rates for patients with stage III and stage IV cancer were 58.3 per cent and 50.0 per cent in the PLCC groups, 48.0 per cent and 15.4 per cent in MMC groups, and 46.3 per cent and 13.3 per cent in no chemotherapy groups, respectively. In stage IV, the survival rate in PLCC group was significantly higher than that in MMC or no chemotherapy group (p<0.05). In the PLCC group, there was a tendency toward a dose-dependent effect in each group, and 5 year survival rate of stage III group administered over 60 mg of MMC, 60 g of FT-207 and 270 g of PSK was 70 per cent, such being remarkably higher than 46.3 per cent in those given no chemotherapy (p<0.07). There was no drug related death and only a slight leukopenia and hepatotoxicity occurred in some patients.

Key Words

postoperative long-term cancer chemotherapy curatively resected gastric carcinoma combination chemotherapy 

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References

  1. 1.
    Jinnai, D.: Evaluation of extended radical operation for gastric cancer, with regard to lymph node metastasis and follow up results. Gann 3: 225–231, 1968.Google Scholar
  2. 2.
    Kodama, Y., Sugimachi, K., Soejima, K., Matsusaka, T. and Inokuchi, K. Evaluation of extensive lymph node dissection for carcinoma of the stomach. World J. Surg. 5: 241–248, 1981.PubMedCrossRefGoogle Scholar
  3. 3.
    Carter, S. K. and Comis, R. L.: Gastric cancer: Current status of treatment. J. Natl. Cancer Inst. 58: 567–578, 1977.PubMedGoogle Scholar
  4. 4.
    Longmire, W. P. Jr., Kuzma, J. W. and Dixon, W. J.: The use of triethylenethiophosphoramide as an adjuvant to the surgical treatment of gastric carcinoma. Ann. Surg. 167: 293–312, 1968.PubMedGoogle Scholar
  5. 5.
    Kaibara, N., Soejima, K., Nakamura, T. and Inokuchi, K.: Postoperative long term chemotherapy for advanced gastric cancer. Jpn. J. Surg. 6: 54–59, 1976.PubMedCrossRefGoogle Scholar
  6. 6.
    Japanese Research Society for Gastric Cancer: The General Rules for Gastric Cancer Study in Surgery and Pathology. Jpn. J Surg. 11: 127–129, 1981.CrossRefGoogle Scholar
  7. 7.
    Karrar, K.: Importance of dose schedules in adjuvant chemotherapy. Cancer Chemotherapy Rep. 56: 35–45, 1972.Google Scholar
  8. 8.
    Kano, T., Tamada, R., Abe, Y., Hiramoto, Y., Notsuka, T., Shirashi, M., Inoue, F., Kumashiro, R., Kodama, Y. and Inokuchi, K.: Postoperative Long-term Cancer Chemotherapy (PLCC) extends life-span of non-curatively resected patients with stage IV gastric cancer. Jpn. J. Surg. 12: 12: 203–207, 1982.PubMedCrossRefGoogle Scholar
  9. 9.
    Hattori, T., Niimoto, M., Koh, T., Nakano, A., Oride, M., Takiyama, W. and Nishimawari, K.: Postoperative long term adjuvant immunochemotherapy with Mitomycin C, PSK andBT-207 in gastric cancer patients. Jpn. J. Surg. 9: 110–117, 1979.PubMedCrossRefGoogle Scholar
  10. 10.
    Fujimoto, S., Akao, T., Itoh, B., Koshizuka, I., Koyano, K., Kitsukawa, Y., Takahashi, M., Minami, T., Ishigami, H., Kure, M., Itoh, K. and Hirosaka, T.: Protracted oral chemotherapy with fluorinated pyrimidines as an adjuvant to surgical treatment for stomach cancer. Ann. Surg. 185: 462–466, 1977.PubMedGoogle Scholar
  11. 11.
    Meyer, M., Londer, M., Schreml, W., Schlag, P. and Queisser, W.: A controlled prospective study of adjuvant 5-fluorouracil and BCNU therapy in stomach carcinoma in gastric cancer. 357–360. Springer-Verlag, Berlin, Heidelberg, New York, 1979.Google Scholar
  12. 12.
    Imanaga, H. and Nakazato, H.: Results of surgery for gastric cancer and effect of adjuvant Mitomycin-C on cancer recurrence, World J. Surg. 1: 213–221, 1977.CrossRefGoogle Scholar
  13. 13.
    Reitemeier, R. J., Moertel, C. G. and Hahn, R. G.: Combination chemotherapy in gastrointestinal cancer. Cancer Res. 30: 1425–1428, 1970.PubMedGoogle Scholar
  14. 14.
    Moertel, C. G.: Clinical management of advanced gastrointestinal cancer. Cancer 36: 675–682, 1975.PubMedCrossRefGoogle Scholar
  15. 15.
    Inokuchi, K. and Tamada, R.: Three prospective controlled studies—part 3—, J. Clinical Surgery 36: 197–204, 1981.Google Scholar

Copyright information

© The Japan Surgical Society 1983

Authors and Affiliations

  • Tadashi Kano
    • 1
  • Ryunosuke Kumashiro
    • 1
  • Hidetaka Masuda
    • 1
  • Ryuichiro Tamada
    • 1
  • Kiyoshi Inokuchi
    • 1
  1. 1.The Second Department of SurgeryKyushu UniversityFukuokaJapan

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