Acquired B antigen and polyagglutination in a patient with gastric cancer

  • Sho Matsushita
  • Takashi Imamura
  • Tomohiro Mizuta
  • Motosuke Hanada
Short Communications


Erythrocytes from a patient with blood type of A1 became nongenetically reactive with A (anti-B) serum, following the development of gastric cancer. Transient polyagglutinability was also apparent. Thein vitro acetylation of the erythrocyte antigens abolished both the acquired B antigen and the polyagglutination. Although incubation of the heterologous type A1 erythrocytes with the patient's serum did not produce B antigen, deacetylase activity in the serum seems to relate to the acquired B antigen. In this case, either ileus as a result of metastatic adenocarcinoma of the stomach, or urinary tract infections could be the cause of the acquired B antigen.

Key Words

blood type acquired B antigen deacetylase 


  1. 1.
    Marcus, D. M., Kabat, E. A. and Shiffman, G.: Immunological studies on blood groups. XXXI. Destruction of blood group A activity by an enzyme fromClostridium tertium which deacetylates N-acetylgalactosamine in intact blood group substances. Biochemistry, 3: 437–443, 1964.PubMedCrossRefGoogle Scholar
  2. 2.
    Cameron, C., Graham, F., Dunsford, I., Sickles, G., Macpherson, C. R., Cahan, A. and Sanger, R.: Acquisition of a B-like antigen by red blood cells. Brit. Med. J. ii: 29–32, 1959.Google Scholar
  3. 3.
    Sasaki, M., Kaneda, H., Nagao, E. and Matsumoto, K.: Abrupt appearance of weak reactivity with anti-B serum in blood group A patient. Rinsho Byori XI: 619–623, 1965. (in Japanese)Google Scholar
  4. 4.
    Marantz, C. and Dimmette, R. M.: More about an acquired group B antigen. Transfusion 9: 160–161, 1969.PubMedGoogle Scholar
  5. 5.
    Beck, M. L., Walker, R. H. and Oberman, H. A.: Atypical polyagglutination associated with an acquired B antigen. Transfusion 11: 296–301, 1971.PubMedCrossRefGoogle Scholar
  6. 6.
    Gerbal, A., Ropars, C., Gerbal, R., Carton, J. P., Maslet, C. and Salmon, C.: Acquired B antigen disappearance byin vitro acetylation associated with A1 activity restoration. Vox Sang 31: 64–66, 1976.PubMedGoogle Scholar
  7. 7.
    Gerbal, A., Maslet, M. and Salmon, C.: Immunological aspects of the acquired B antigen. Vox Sang 28: 398–403, 1975.PubMedCrossRefGoogle Scholar
  8. 8.
    Kline, W. E., Sullivan, C. M., Bowman, R. J. and Linden, M.: Acquired B antigen and polyagglutination in an apparently healthy blood donor. Transfus. Immunohematol. 25: 119–126, 1982.PubMedCrossRefGoogle Scholar

Copyright information

© The Japan Surgical Society 1983

Authors and Affiliations

  • Sho Matsushita
    • 1
  • Takashi Imamura
    • 1
  • Tomohiro Mizuta
    • 2
  • Motosuke Hanada
    • 2
  1. 1.First Department of Internal Medicine, Faculty of MedicineKyushu UniversityFukuokaJapan
  2. 2.Sanshinkai Hara HospitalFukuokaJapan

Personalised recommendations