Gastric carcinoma with lymphoid stroma: Correlation to reactive hyperplasia in regional lymph nodes and prognosis
- 22 Downloads
The pathological changes of regional lymph nodes in cases of gastric carcinomas with lymphoid stroma (LS group) and the prognostic significance of the findings were studied in comparison with those in cases of ordinary stroma (OS group). The purpose of this study was to elucidate the immune responses of regional lymph nodes, histologically, in patients with gastric carcinoma and lymphoid stroma. In the LS group, the incidence of paracortical hyperplasia (PH) was high, irrespective of lymph node metastasis, while that of germinal center hyperplasia (GH) was high in the absence of lymph node metastasis but tended to be low in the presence of metastasis. In the OS group, the incidences of PH and GH were low, particularly in the presence of lymph node metastasis. The five year survival rate in those with no lymph node metastasis was as favorable as that of patients with lymph node metastasis in the LS group, the latter being significantly higher than the rate in the OS group. These results indicate that gastric carcinomas with lymphoid stroma are closely related to reactive hyperplasias of the regional lymph nodes, particularly paracortical hyperplasia, and in such cases, there is a favorable prognosis, regardless of the lymph node metastasis.
Key Wordsgastric carcinoma lymphoid stroma lymph node paracortical hyperplasia germinal center hyperplasia
Unable to display preview. Download preview PDF.
- 5.Hamazaki, M., Sawayama, K., and Kuriya, T.: Stomach cancer with lymphoid stroma. J. Karyopathol. 12: 115–120, 1968. (in Japanese).Google Scholar
- 7.MacCarty, W.C. and Mahle, A.E.: Relation of differentiation and lymphocytic infilatration to postoperative longevity in gastric carcinoma. J. Lab. Clin. Med. 6: 473–480, 1922.Google Scholar
- 10.Shirakusa, T.: Blood-vessel invasion and lymphoid reaction in carcinoma of lung. Fukuoka Acta. Medica. 68: 225–246, 1977. (in Japanese)Google Scholar
- 12.Toyoshima, S. and Enjoji, M.: Histological representations of host resistance in mammary carcinoma. Fukuoka Acta. Medica. 66: 387–396, 1975. (in Japanese)Google Scholar
- 14.Eric, P., Richard, C.N., Barrie, J.M., Alan, M.C., Edward, S.R.H. and Alex, R.: Lymphoid hyperplasia. A major prognostic feature in 519 cases of colorectal carcinoma. Am. J. Pathol. 100: 469–480, 1980.Google Scholar
- 19.Oort, J. and Turk, J.L.: A histological and autoradiographic study of lymph nodes during the development of contact sensitivity in the guineapig. Brit. J. Exp. Path. 46: 147–154, 1964.Google Scholar
- 21.Wheater, P.R., Burkitt, H.G. and Daniel, V.G.: Immune system. in Functional Histology, pp. 145–160, Churchill Livingstone, Edinburgh, London & New York, 1979.Google Scholar
- 22.Miale, J.B. and Rywlin, A.M.: Nonspecific reactive hyperplasia of lymph nodes in Pathology, 7th ed., vol. 2, pp. 1515–1517, eds. Anderson, W.A.D. and Kissane, J.M. C.V. Mosby Co., Saint Louis, 1977.Google Scholar
- 23.Kitagawa, T., Miwa, H., Nakamura, K., Matsui, A., Sogabe, K. and Orita, K.: Lymphoid infiltration in cancer and cell-mediated immunity in gastric cancer. Jpn. J. Gastroenterol. Surg. 14: 1178–1184, 1981. (in Japanese)Google Scholar