Response of plasma renin activity during surgical stress
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Variation of plasma renin activity was studied at the intervals of 10 to 20 min during partial gastrectomy of our clinical cases, and the relationships between circulating plasma volume and serum electrolytes were also studied to find a clue on the secretary mechanism of renin during surgical stress. The operation was performed under halothane-N2O−O2 anesthesia. Blood losses due to sampling and surgical procedure were carefully replaced. Plasma renin activity gradually increased from the beginning of surgical procedure and reached maximum between the later part of the operative period and the 3rd postoperative day, then decreased to normal by the 7th or 14th postoperative day in most cases. Maximum level of plasma renin activity due to surgical manipulation ranged from two to twenty fold of the normal value. Significant reverse correlation between plasma renin activity and circulating plasma volume was observed. The elevation of plasma renin activity followed the decrease of circulating plasma volume. Whereas, arterial pressure was maintained almost constant during surgery. Serum sodium and potassium concentrations were all within normal range and were unrelated to the variation of plasma renin activity during surgical stress.
Key Wordsplasma renin activity electrolytes plasma volume surgical stress
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