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High performance liquid chromatography method for the determination of meropenem in human plasma

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Summary

This paper describes an HPLC method for the determination of meropenem in human plasma. The method uses solid phase extraction (SPE) of the samples and has good sensitivity, precision and accuracy. The limit of quantification in plasma samples is 0.02 μg mL−1. Calibration curves were linear over a large dynamic range, namely within 0.02–50 μg mL−1. The method was applied to the determination of meropenem levels in patients receiving meropenem, as a single dose or at steady state.

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Farin, D., Kitzes-Cohen, R., Piva, G. et al. High performance liquid chromatography method for the determination of meropenem in human plasma. Chromatographia 49, 253–255 (1999). https://doi.org/10.1007/BF02467552

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Key Words

  • Column liquid chromatography
  • Meropenem in human plasma
  • Solid phase extraction