, Volume 47, Issue 7–8, pp 465–469 | Cite as

Applications of molecularly imprinted materials as selective adsorbents: Emphasis on enzymatic equilibrium shifting and library screening

  • O. Ramström
  • L. Ye
  • M. Krook
  • K. Mosbach
Papers Presented at: Affinity Chromatography Conference, Cambridge (UK), July 1–3, 1997 Original


Molecular imprinting is an attractive method for producing highly selective adsorbents, and several new and potentially useful applications based on molecularly imprinted polymers (MIPs) have been described in recent years. In this article, we highlight some of the areas where these materials have found application, and also describe some new fields of application where the selectivities of imprinted materials can be gainfully employed, for example as binding matrices in the screening of combinatorial libraries, and as auxiliary agents in enzymatic syntheses.

Key Words

Column liquid chromatography Affinity chromatography Molecular imprinting Molecular recognition Combinatorial libraries 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. [1]
    K. Mosbach, O. Ramström, Bio/Technology14, 163 (1996).CrossRefGoogle Scholar
  2. [2]
    G. Wulff, Angew. Chem. Int. Ed. Engl.34, 1812 (1995).CrossRefGoogle Scholar
  3. [3]
    S. Vidyasankar, F. H. Arnold, Curr. Opin. Biotechnol.6, 218 (1995).CrossRefGoogle Scholar
  4. [4]
    K. J. Shea, Trends Polym. Sci. (Cambridge, U.K.)2, 166 (1994).Google Scholar
  5. [5]
    M. Kempe, K. Mosbach, J. Chromatogr. A694, 3 (1995).CrossRefGoogle Scholar
  6. [6]
    R. J. Ansell, O. Ramström, K. Mosbach, Clin. Chem.42, 1506 (1996).Google Scholar
  7. [7]
    X. C. Liu, K. Mosbach, Macromol. Rapid Commun18, 609 (1997).CrossRefGoogle Scholar
  8. [8]
    M. E. Davis, A. Katz, W. R. Ahmad, Chem. Mater.8, 1820 (1996).CrossRefGoogle Scholar
  9. [9]
    D. Kriz, O. Ramström, K. Mosbach, Anal. Chem.69, A345 (1997).Google Scholar
  10. [10]
    G. Vlatakis, L. I. Andersson, R. Müller, K. Mosbach, Nature361, 645 (1993).CrossRefGoogle Scholar
  11. [11]
    L. I. Andersson, R. Müller, G. Vlatakis, K. Mosbach, Proc. Natl. Acad. Sci. USA92, 4788 (1995).CrossRefGoogle Scholar
  12. [12]
    M. Senholdt, M. Siemann, K. Mosbach, L. I. Andersson, Anal. Lett.30, 1809 (1997).Google Scholar
  13. [13]
    M. Siemann, L. I. Andersson, K. Mosbach, J. Antibiotics50, 88 (1997).Google Scholar
  14. [14]
    L. I. Andersson, Anal. Chem.68, 111 (1996).CrossRefGoogle Scholar
  15. [15]
    H. Fenniri, Curr. Med. Chem.3, 343 (1996).Google Scholar
  16. [16]
    G. P. Smith, V. A. Petrenko, Chem. Rev.97, 391 (1997).CrossRefGoogle Scholar
  17. [17]
    S. E. Osborne, A. D. Ellington, Chem. Rev.97, 349 (1997).CrossRefGoogle Scholar
  18. [18]
    K. S. Lam, M. Lebl, V. Krchňák, Chem. Rev.97, 411 (1997).CrossRefGoogle Scholar
  19. [19]
    M. Kempe, K. Mosbach, J. Chromatogr.664, 276 (1994).CrossRefGoogle Scholar
  20. [20]
    L. Fischer, R. Müller, B. Ekberg, K. Mosbach, J. Am. Chem. Soc.113, 9358 (1991).CrossRefGoogle Scholar
  21. [21]
    L. I. Andersson, D. J. O. Shannessy, K. Mosbach, J. Chromatogr.516, 167 (1990).CrossRefGoogle Scholar
  22. [22]
    M. Siemann, L. I. Andersson, K. Mosbach, J. Agric. Food Chem.44, 141 (1996).CrossRefGoogle Scholar
  23. [23]
    J. Berglund, C. Lindbladh, I. A. Nicholls, K. Mosbach, Manuscript (1997).Google Scholar
  24. [24]
    K. Nakanishi, T. Kamikubo, R. Matsuno, Bio/Technology3, 459 (1985).CrossRefGoogle Scholar
  25. [25]
    L. Ye, O. Ramström, M.-O. Månsson, Manuscript (1997).Google Scholar

Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1998

Authors and Affiliations

  • O. Ramström
    • 1
  • L. Ye
    • 1
  • M. Krook
    • 1
  • K. Mosbach
    • 1
  1. 1.Pure and Applied Biochemistry, Center for Chemistry and Chemical EngineeringLund UniversityLundSweden

Personalised recommendations