, Volume 37, Issue 1, pp 71–80 | Cite as

Critical evaluation of the VSC model for tip growth

  • I. Brent Heath
  • E. J. Janse van Rensburg
Original Papers


The vesicle supply centre (VSC) model (Bartnicki-Garcia et al., 1989) for hyphal tip growth is powerful because it can model diverse developmental morphologies and predicts cellular organization based in current cell biology. It predicts that tip growth results from the random distribution of cell surface synthesizing vesicles from a point in the tip, the VSC, which determines their pattern of impact and fusion at the plasma membrane. We derive equations for tip-high gradients of vesicle fusions, generated by mechanisms not related to a supply centre, which create typical hyphal morphologies. These equations direct the conceptual basis for tip growth to vesicle fusion gradients, presumably mediated by a putative membrane skeleton associated with the plasma membrane. We also show that the organization and behaviour of motile organelles in growing hyphal tips of the oomycete,Saprolegnia ferax, argue against the presence of an apparatus capable of generating the distribution of vesicles postulated by the VSC model. We conclude that the VSC model is unlikely to describe the mechanistic basis of tip growth inS. ferax, and therefore, at best, it is not universally applicable.

Key Words

mathematical model Saprolegnia ferax tip growth VSC model 


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Literature cited

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Copyright information

© The Mycological Society of Japan 1996

Authors and Affiliations

  • I. Brent Heath
    • 1
  • E. J. Janse van Rensburg
    • 2
  1. 1.Biology, DepartmentYork UniversityTorontoCanada
  2. 2.Mathematics and Statistics DepartmentYork UniversityTorontoCanada

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