Neuroscience and Behavioral Physiology

, Volume 29, Issue 4, pp 359–363 | Cite as

Pre- and postsynaptic mechanisms of the involvement of amygdaloid complex serotonin in the reproduction of a conditioned passive avoidance response in rats

  • G. F. Molodtsova
  • R. Yu. Il'yuchenok
Article
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Abstract

Serotonin metabolism and [3H]-serotonin radioligand receptor binding were studied in the amygdaloid complex of the rat brain at different stages of a conditioned passive avoidance response. Serotoninergic changes were specific for the process of reproduction of the conditioned response. The involvement of serotonin in the amygaloid complex during reproduction of memory traces consisted of a reduction in its postsynaptic receptor binding. The serotonin level in the amygaloid complex did not change, while changes in serotonin metabolism detected during reproduction of the conditioned avoidance response were associated with an increase in its deamination by monoamine oxidase and an increase in the active transport of 5-hydroxyindoleacetic acid from nerve terminals.

Keywords

Serotonin Conditioned Response Passive Avoidance Avoidance Response Memory Trace 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. 1.
    V. M. Getsova and M. Uniyal, “The effects of decreasing the brain serotonin content on the development and retention of conditioned defensive reflexes,”Zh. Vyssh. Nerv. Deyat.,28, No. 1, 115 (1978).Google Scholar
  2. 2.
    V. Z. Gorkin,Amine Oxidases and their Importance in Medicine [in Russian]. Meditsina, Moscow (1981), p. 34.Google Scholar
  3. 3.
    R. Yu. Il'yuchenok, M. A. Gilinskii, L. V. Loskutova, et al.,The Amygdaloid Complex (Connections, Behavior, Memory) [in Russian], Nauka, Novosibirsk (1981).Google Scholar
  4. 4.
    E. Cornish-Bowden,The Bases of Enzyme Kinetics [Russian translation], Mir, Moscow (1979).Google Scholar
  5. 5.
    R. I. Kruglikov,Neurochemical Mechanisms of Learning and Memory [in Russian], Nauka, Moscow (1981).Google Scholar
  6. 6.
    É. M. Melikov and E. O. Bairamova, “Monoaminergic control of the reinforcing effects of conditioned stimuli by the nuclei of the amygdala,”Zh. Vyssh. Nerv. Deyat.,44, No. 2, 254 (1994).Google Scholar
  7. 7.
    G. F. Molodtsova, “Regional and seasonal differences in [3H]serotonin binding in the rat brain,”Neirokhimiya,8, No. 2, 259 (1989).Google Scholar
  8. 8.
    G. F. Molodtsova and L. V. Loskutova, “Monoamine oxidase activity and serotonin metabolism in the rat brain in latent inhibition,”Byull. Éksp. Biol. Med.,114, No. 2, 568 (1992).Google Scholar
  9. 9.
    P. V. Simonov, “The nervous centers of the emotions,”Zh. Vyssh. Nerv. Deyat.,43, No. 3, 514 (1993).Google Scholar
  10. 10.
    G. K. Aghajanian, “Electrophysiology of serotonin receptor subtypes and signal transduction pathways,” in:Psychopharmacology: The Fourth Generation of Progress, F. E. Bloom and D. J. Kupfer (Eds.), Raven Press, New York (1995), p. 451.Google Scholar
  11. 11.
    F. Borsini, A. Ceci, G. Biett, and A. Donetti, “BIMT17,5-HT1A receptor agonist/5-HT2A receptor antagonist, directly activates postsynaptic 5-HT inhibitory responses in the rat cerebral cortex,”Naunyn-Schmiedelbergs Arch. Pharmacol.,352, 283 (1995).Google Scholar
  12. 12.
    M. Carli and R. Samanin, “8-Hydroxy-2(di-n-propylamino)tetralin impairs spatial learning in a water maze: Role of postsynaptic 5-HT1A receptors,”Brit. J. Pharmacol.,105, No. 3, 720 (1992).Google Scholar
  13. 13.
    G. Curzon and A. R. Green, “Rapid method for the determination of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in small regions of rat brain,”Brit. J. Pharmacol.,39, 653 (1970).Google Scholar
  14. 14.
    H. A. Feldman, “Mathematical theory of complex ligand-binding systems at equilibrium: some methods for parameter fitting,”Anal. Biochem.,48, 317 (1972).PubMedCrossRefGoogle Scholar
  15. 15.
    A. J. Hunter, “Serotonergic involvement in learning and memory,”Biochem. Soc. Trans.,17, No. 1, 79 (1989).PubMedGoogle Scholar
  16. 16.
    M. E. Jarvic and R. Kopp, “An improved one-trial passive avoidance learning situation,”Physiol. Rept.,21, 221 (1967).Google Scholar
  17. 17.
    C. A. Lorenzini, C. Bucharelli, A. Giachetti, et al., “Effects of nucleus basolateralis amygdalae neurotoxic lesions on aversive conditioning in the rat,”Physiol. Behav.,49, No. 4, 765 (1991).CrossRefGoogle Scholar
  18. 18.
    J. L. McGaugh, I. B. Introni-Collison, L. F. Cahill, et al., “Neuromodulatory systems and memory storage: Role of the amygdala,”Behav. Brain Res.,58, 81 (1993).PubMedCrossRefGoogle Scholar
  19. 19.
    A. Meneses and E. Hong, “A pharmacological analysis of serotonergic receptors: Effects of their activation or blockade in learning,”Progr. Neuro-Psychopharmacol. Biol. Psychiatr.,21, No. 2, 273 (1997).CrossRefGoogle Scholar
  20. 20.
    N. H. Neff, T. N. Tozer, and B. B. Brodie, “Application of steady-state kinetics to studies of the transfer of 5-hydroxyindoleacetic acid from brain to plasma,”J. Pharmacol. Exptl. Therap.,158, No. 2, 214 (1967).Google Scholar
  21. 21.
    S.-O. Ogren, “Central serotonin neurones and learning in the rat,” in:Biology of Serotonergic Transmission, N. N. Osborne (Ed.), John Wiley & Sons Ltd., New York (1982), p. 317.Google Scholar
  22. 22.
    T. Ono, H. Nishijo, and T. Uwano, “Amygdala: Role in conditioned associative learning,”Progr. Neurobiol.,46, 401 (1995).PubMedCrossRefGoogle Scholar
  23. 23.
    D. Quartermain, J. Clemente, and A. Shemer, “The 5-HT(1A) agonist tandospirone disrupts retention but not acquisition of active avoidance learning,”Pharmacol. Biochem. Behav.,48, No. 3, 805 (1994).PubMedCrossRefGoogle Scholar
  24. 24.
    P. Riekinnen, “5-HT(1A) and muscarinic acetylcholine receptors jointly regulate passive avoidance behavior,”Eur. J. Pharmacol.,262, No. 1–2, 77 (1994).CrossRefGoogle Scholar
  25. 25.
    M. Sarter and H. J. Markowitsch, “Involvement of the amygdala in learning and memory: A critical review with emphasis on anatomical relations,”Behav. Neurosci.,99, No. 2, 342 (1985).PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • G. F. Molodtsova
  • R. Yu. Il'yuchenok
    • 1
  1. 1.Cognitive Activity Physiology Laboratory, Memory Regulation Laboratory, Institute of Physiology, Siberian DivisionRussian Academy of Medical SciencesNovosibirsk

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