Bulletin of Mathematical Biology

, Volume 56, Issue 3, pp 391–410 | Cite as

Ascending myogenic autoregulation: Interactions between tubuloglomerular feedback and myogenic mechanisms

  • Leon C. Moore
  • Adam Rich
  • Daniel Casellas
Article
Received:

Abstract

A mathematical model of the renal vascular and tubular systems was used to examine the possibility that synergistic interactions might occur between the tubuloglomerular feedback (TGF) and myogenic autoregulatory mechanisms in the kidney. To simulate the myogenic mechanism, the renal vasculature was modelled with a resistance network where the total preglomerular resistance varies with intravascular pressure. In addition, a steady-state model of glomerular filtration, proximal and Henle's loop reabsorption, and TGF-modulation of afferent arteriolar resistance was derived. The results show that, if TGF acts on the distal portion of the preglomerular vasculature, then any TGF-induced vasoconstriction should raise upstream intravascular pressure and, thereby, trigger a myogenic response in the more proximal vascular segments, a phenomenon referred to as an ascending myogenic (AMYO) response. The model further predicts that the magnitude of the AMYO response can be similar in magnitude to the TGF-induced increment in afferent resistance. Hence, the effects of TGF excitation on whole kidney hemodynamics may be much greater than pedicted from measurements in single nephrons. Moreover, a significant fraction of the intrinsic myogenic autoregulatory response to increased renal perfusion pressure may result from a synergistic interaction between the TGF and myogenic mechanisms.

Keywords

Afferent Arteriole Tubular Fluid Myogenic Response Intravascular Pressure Tubuloglomerular Feedback 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature

  1. Carmines, P. K., E. W. Inscho and R. C. Gensure. 1990. Arterial pressure effects on preglomerular microvasculature of juxtamedullary nephrons.Am. J. Physiol.,258, F94-F102.Google Scholar
  2. Casellas, D. and L. C. Moore. 1990. Autoregulation and tubuloglomerular feedback in juxtamedullary glomerular arterioles.Am. J. Physiol. 258, F660-F669.Google Scholar
  3. Casellas, D. and L. C. Moore, 1993. Autoregulation of intravascular pressure in preglomerular juxtamedullary vessels.Am. J. Physiol. 264, F315-F321.Google Scholar
  4. Chou, C. L. and D. J. Marsh. 1987. Measurement of flow rate in rat proximal tubules with a nonobstructive optical method.Am. J. Physiol. 253, F366-F371.Google Scholar
  5. Davis, J. M., D. Häberle and T. Kawata. 1988a. The control of glomerular filtration rate and renal blood flow in chronically volume expanded rats.J. Physiol. 402, 473–495.Google Scholar
  6. Davis, J. M., D. Häberle, T. Kawata, E. Schmitt, T. Takabatake and S. Wohlfeil. 1988b. Increased tubuloglomerular feedback mediated suppression of glomerular filtration during acute volume expansion.J. Physiol. 395, 553–576.Google Scholar
  7. Häberle, D. A. Hemodynamic interactions between intrinsic blood flow control mechanisms in the rat kidney.Renal Physiol. Biochem. 11, 289–315.Google Scholar
  8. Heyeraas, K. and K. Aukland. 1987. Interlobular resistance: Influence of renal arterial pressure and angiotensin II.Kidney Int. 31, 1291–1298.Google Scholar
  9. Huss, R. E., D. J. Marsh and R. E. Kalaba. 1975. Two models of glomerular filtration rate and renal blood flow in the rat.Ann. biomed. Engng 3, 72–99.Google Scholar
  10. Johnson, P. C. 1986. Autoregulation of blood flow.Circ. Res. 59, 483–495.Google Scholar
  11. Källskog, Ö., L. O. Lindbom, H. R. Ulfendahl and M. Wolgast. 1976. Hydrostatic pressures within the vascular structures of the rat kidney.Pflügers Arch. ges. Physiol. 363, 205–210.CrossRefGoogle Scholar
  12. Kaskel, F. J., P. Devarajan, A. Birzgalis and L. C. Moore. 1989. Inhibition of myogenic autoregulation in cyclosporine nephrotoxicity in the rat.Renal physiol. Biochem. 12, 250–259.Google Scholar
  13. Mason, J., H. U. Gutsche, L. C. Moore and R. Müller-Suur. 1978. The early phase of acute renal failure. IV. The diluting ability of the short loops of Henle.Pflügers Arch. ges. Physiol. 379, 11–18.Google Scholar
  14. Moore, L. C. 1984. Tubuloglomerular feedback and SNGFR autoregulation in the rat.Am. J. Physiol. 247, F267-F276.Google Scholar
  15. Moore, L. C. and D. Casellas. 1990. Tubuloglomerular feedback dependence of autoregulation in rat juxtamedullary afferent arterioles.Kidney Int. 37, 1402–1408.Google Scholar
  16. Moore, L. C. and J. Mason. 1983. Perturbation analysis of tubuloglomerular feedback in hydropenic and hemorrhaged rats.Am. J. Physiol. 245, F554-F563.Google Scholar
  17. Øien, A. H. and K. Aukland. 1983. A mathematical analysis of the myogenic hypothesis with special reference to autoregulation of renal blood flow.Circ. Res. 52, 241–252.Google Scholar
  18. Persson, A. E. G. and F. S. Wright. 1982. Evidence for feedback mediated reduction of glomerular filtration during infusion of acetazolamide.Acta physiol. Scand. 114, 1–7.CrossRefGoogle Scholar
  19. Schnermann, J. and J. P. Briggs. 1989. Interaction between loop of Henle flow and arterial pressure as determinants of glomerular pressure.Am. J. Physiol. 256, F421-F429.Google Scholar
  20. Schnermann, J. and J. P. Briggs. 1992. Function of the juxtaglomerular apparatus: control of glomerular hemodynamics and renin secretion. In:The Kidney: Physiology and Pathophysiology, 2nd edn. D. W. Seldin and G. Giebisch (Eds), pp. 1053–1068, New York: Raven Press.Google Scholar
  21. Steinhausen, M., M. Blum, J. T. Fleming, F. G. Holz, N. Parekh and D. L. Weigman. 1989. Visualization of renal autoregulation in the split hydronephrotic kidney of rats.Kidney Int. 35, 1151–1160.Google Scholar
  22. Tucker, B. J., R. W. Steiner, L. C. Gushwa and R. C. Blantz. 1978. Studies on the tubuloglomerular feedback system in the rat: the mechanism of reduction in filtration rate with benzolamide.J. clin. Invest. 62, 993–1004.CrossRefGoogle Scholar
  23. Ulfendahl, H. R. and M. Wolgast. 1992. Renal circulation and lymphatics. In:The Kidney: Physiology and Pathophysiology, 2nd edn. D. W. Seldin and G. Giebisch (Eds), pp. 1018–1022, New York: Raven Press.Google Scholar

Copyright information

© Elsevier Science Ltd 1994

Authors and Affiliations

  • Leon C. Moore
    • 1
    • 2
  • Adam Rich
    • 1
    • 2
  • Daniel Casellas
    • 1
    • 2
  1. 1.Department of Physiology and BiophysicsState University of New YorkStony BrookU.S.A.
  2. 2.Groupe Rein et HypertensionHôpital St. CharlesMontpellier CedexFrance

Personalised recommendations