Bulletin of Mathematical Biology

, Volume 48, Issue 1, pp 21–27 | Cite as

A model for cooperative ligand binding at complementary sites of DNA

  • Subhendu Ghosh
  • Anjali Mookerjee
Article
Received:
Revised:

Abstract

The process of cooperative binding of ligands to DNA has been classified into different modes. An additional mode of cooperative interaction amongst ligands binding at sites on complementary strands has been emphasised. A statistical mechanical method has been applied to obtain an analytical expression for the fraction of nucleotide sites bound. Theoretical Scatchard plots have been drawn and analysed.

Keywords

Acridine Scatchard Plot Cooperative Binding Complementary Site Large Ligand 
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Copyright information

© Society for Mathematical Biology 1986

Authors and Affiliations

  • Subhendu Ghosh
    • 1
  • Anjali Mookerjee
    • 1
  1. 1.School of Environmental SciencesJawaharlal Nehru UniversityNew DelhiIndia

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